A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Nucleic acids through condensation of nucleosides and phosphorous acid in the presence of sulfur
Tekijät: Lonnberg T
Kustantaja: BEILSTEIN-INSTITUT
Julkaisuvuosi: 2016
Journal: Beilstein Journal of Organic Chemistry
Tietokannassa oleva lehden nimi: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Lehden akronyymi: BEILSTEIN J ORG CHEM
Vuosikerta: 12
Aloitussivu: 670
Lopetussivu: 673
Sivujen määrä: 4
ISSN: 1860-5397
DOI: https://doi.org/10.3762/bjoc.12.67
Tiivistelmä
Short phosphorothioate oligonucleotides have been prepared by refluxing an equimolar mixture of thymidine and triethylammonium phosphite in toluene in the presence of elemental sulfur. Desulfurization and subsequent digestion of the products by P1 nuclease revealed that nearly 80% of the internucleosidic linkages thus formed were of the canonical 3',5'-type.
Short phosphorothioate oligonucleotides have been prepared by refluxing an equimolar mixture of thymidine and triethylammonium phosphite in toluene in the presence of elemental sulfur. Desulfurization and subsequent digestion of the products by P1 nuclease revealed that nearly 80% of the internucleosidic linkages thus formed were of the canonical 3',5'-type.
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