A1 Refereed original research article in a scientific journal
Nucleic acids through condensation of nucleosides and phosphorous acid in the presence of sulfur
Authors: Lonnberg T
Publisher: BEILSTEIN-INSTITUT
Publication year: 2016
Journal: Beilstein Journal of Organic Chemistry
Journal name in source: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Journal acronym: BEILSTEIN J ORG CHEM
Volume: 12
First page : 670
Last page: 673
Number of pages: 4
ISSN: 1860-5397
DOI: https://doi.org/10.3762/bjoc.12.67(external)
Abstract
Short phosphorothioate oligonucleotides have been prepared by refluxing an equimolar mixture of thymidine and triethylammonium phosphite in toluene in the presence of elemental sulfur. Desulfurization and subsequent digestion of the products by P1 nuclease revealed that nearly 80% of the internucleosidic linkages thus formed were of the canonical 3',5'-type.
Short phosphorothioate oligonucleotides have been prepared by refluxing an equimolar mixture of thymidine and triethylammonium phosphite in toluene in the presence of elemental sulfur. Desulfurization and subsequent digestion of the products by P1 nuclease revealed that nearly 80% of the internucleosidic linkages thus formed were of the canonical 3',5'-type.
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