Rifampin Greatly Reduces the Plasma Concentrations of Intravenous and Oral Oxycodone

: Nieminen TH, Hagelberg NM, Saari TI, Pertovaara A, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2009

: Anesthesiology

: ANESTHESIOLOGY

: 110

: 6

: 1371

: 1378

: 8

: 0003-3022

DOI: https://doi.org/10.1097/ALN.0b013e31819faa54

Conclusions: Induction of cytochrome P450 3A by rifampin reduced the area under the oxycodone concentration-time curve of intravenous and oral oxycodone. The pharmacologic effects of oxycodone were modestly attenuated. To maintain adequate analgesia, dose adjustment of oxycodone may be necessary, when used concomitantly with rifampin.