A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Rifampin Greatly Reduces the Plasma Concentrations of Intravenous and Oral Oxycodone
Tekijät: Nieminen TH, Hagelberg NM, Saari TI, Pertovaara A, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2009
Journal: Anesthesiology
Tietokannassa oleva lehden nimi: ANESTHESIOLOGY
Lehden akronyymi: ANESTHESIOLOGY
Vuosikerta: 110
Numero: 6
Aloitussivu: 1371
Lopetussivu: 1378
Sivujen määrä: 8
ISSN: 0003-3022
DOI: https://doi.org/10.1097/ALN.0b013e31819faa54
Tiivistelmä
Conclusions: Induction of cytochrome P450 3A by rifampin reduced the area under the oxycodone concentration-time curve of intravenous and oral oxycodone. The pharmacologic effects of oxycodone were modestly attenuated. To maintain adequate analgesia, dose adjustment of oxycodone may be necessary, when used concomitantly with rifampin.
Conclusions: Induction of cytochrome P450 3A by rifampin reduced the area under the oxycodone concentration-time curve of intravenous and oral oxycodone. The pharmacologic effects of oxycodone were modestly attenuated. To maintain adequate analgesia, dose adjustment of oxycodone may be necessary, when used concomitantly with rifampin.
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