A1 Refereed original research article in a scientific journal
Rifampin Greatly Reduces the Plasma Concentrations of Intravenous and Oral Oxycodone
Authors: Nieminen TH, Hagelberg NM, Saari TI, Pertovaara A, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2009
Journal: Anesthesiology
Journal name in source: ANESTHESIOLOGY
Journal acronym: ANESTHESIOLOGY
Volume: 110
Issue: 6
First page : 1371
Last page: 1378
Number of pages: 8
ISSN: 0003-3022
DOI: https://doi.org/10.1097/ALN.0b013e31819faa54
Abstract
Conclusions: Induction of cytochrome P450 3A by rifampin reduced the area under the oxycodone concentration-time curve of intravenous and oral oxycodone. The pharmacologic effects of oxycodone were modestly attenuated. To maintain adequate analgesia, dose adjustment of oxycodone may be necessary, when used concomitantly with rifampin.
Conclusions: Induction of cytochrome P450 3A by rifampin reduced the area under the oxycodone concentration-time curve of intravenous and oral oxycodone. The pharmacologic effects of oxycodone were modestly attenuated. To maintain adequate analgesia, dose adjustment of oxycodone may be necessary, when used concomitantly with rifampin.
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