St John's wort greatly reduces the concentrations of oral oxycodone

: Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT

Publisher: ELSEVIER SCI LTD

: 2010

: European Journal of Pain

: EUROPEAN JOURNAL OF PAIN

: EUR J PAIN

: 8

: 14

: 8

: 854

: 859

: 6

: 1090-3801

DOI: https://doi.org/10.1016/j.ejpain.2009.12.007

Conclusions: St John's wort greatly reduced the plasma concentrations of oral oxycodone. The self-reported drug effect of oxycodone decreased significantly. This interaction may potentially be of some clinical significance when treating patients with chronic pain. (C) 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.