A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
St John's wort greatly reduces the concentrations of oral oxycodone
Tekijät: Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT
Kustantaja: ELSEVIER SCI LTD
Julkaisuvuosi: 2010
Journal: European Journal of Pain
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF PAIN
Lehden akronyymi: EUR J PAIN
Numero sarjassa: 8
Vuosikerta: 14
Numero: 8
Aloitussivu: 854
Lopetussivu: 859
Sivujen määrä: 6
ISSN: 1090-3801
DOI: https://doi.org/10.1016/j.ejpain.2009.12.007
Tiivistelmä
Conclusions: St John's wort greatly reduced the plasma concentrations of oral oxycodone. The self-reported drug effect of oxycodone decreased significantly. This interaction may potentially be of some clinical significance when treating patients with chronic pain. (C) 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
Conclusions: St John's wort greatly reduced the plasma concentrations of oral oxycodone. The self-reported drug effect of oxycodone decreased significantly. This interaction may potentially be of some clinical significance when treating patients with chronic pain. (C) 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
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