A1 Refereed original research article in a scientific journal
St John's wort greatly reduces the concentrations of oral oxycodone
Authors: Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT
Publisher: ELSEVIER SCI LTD
Publication year: 2010
Journal: European Journal of Pain
Journal name in source: EUROPEAN JOURNAL OF PAIN
Journal acronym: EUR J PAIN
Number in series: 8
Volume: 14
Issue: 8
First page : 854
Last page: 859
Number of pages: 6
ISSN: 1090-3801
DOI: https://doi.org/10.1016/j.ejpain.2009.12.007
Abstract
Conclusions: St John's wort greatly reduced the plasma concentrations of oral oxycodone. The self-reported drug effect of oxycodone decreased significantly. This interaction may potentially be of some clinical significance when treating patients with chronic pain. (C) 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
Conclusions: St John's wort greatly reduced the plasma concentrations of oral oxycodone. The self-reported drug effect of oxycodone decreased significantly. This interaction may potentially be of some clinical significance when treating patients with chronic pain. (C) 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
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