Elimination of Intravenous Oxycodone in the Elderly A Pharmacokinetic Study in Postoperative Orthopaedic Patients of Different Age Groups



: Liukas A, Kuusniemi K, Aantaa R, Virolainen P, Neuvonen M, Neuvonen PJ, Olkkola KT

Publisher: ADIS INT LTD

: 2011

: Drugs and Aging

: DRUGS & AGING

: DRUG AGING

: 1

: 28

: 1

: 41

: 50

: 10

: 1170-229X

DOI: https://doi.org/10.2165/11586140-000000000-00000(external)


Conclusions: Age is an important factor affecting the pharmacokinetics of oxycodone. Following intravenous administration of oxycodone, patients aged >70 years are expected to have, on average, 40-80% higher exposure to oxycodone than young adult patients. Because oxycodone pharmacokinetics are greatly dependent on the age of the patient, it is important to titrate the analgesic dose individually, particularly in the elderly.



Last updated on 2024-26-11 at 13:26