A1 Refereed original research article in a scientific journal
Elimination of Intravenous Oxycodone in the Elderly A Pharmacokinetic Study in Postoperative Orthopaedic Patients of Different Age Groups
Authors: Liukas A, Kuusniemi K, Aantaa R, Virolainen P, Neuvonen M, Neuvonen PJ, Olkkola KT
Publisher: ADIS INT LTD
Publication year: 2011
Journal: Drugs and Aging
Journal name in source: DRUGS & AGING
Journal acronym: DRUG AGING
Number in series: 1
Volume: 28
Issue: 1
First page : 41
Last page: 50
Number of pages: 10
ISSN: 1170-229X
DOI: https://doi.org/10.2165/11586140-000000000-00000(external)
Abstract
Conclusions: Age is an important factor affecting the pharmacokinetics of oxycodone. Following intravenous administration of oxycodone, patients aged >70 years are expected to have, on average, 40-80% higher exposure to oxycodone than young adult patients. Because oxycodone pharmacokinetics are greatly dependent on the age of the patient, it is important to titrate the analgesic dose individually, particularly in the elderly.
Conclusions: Age is an important factor affecting the pharmacokinetics of oxycodone. Following intravenous administration of oxycodone, patients aged >70 years are expected to have, on average, 40-80% higher exposure to oxycodone than young adult patients. Because oxycodone pharmacokinetics are greatly dependent on the age of the patient, it is important to titrate the analgesic dose individually, particularly in the elderly.
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