A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Elimination of Intravenous Oxycodone in the Elderly A Pharmacokinetic Study in Postoperative Orthopaedic Patients of Different Age Groups
Tekijät: Liukas A, Kuusniemi K, Aantaa R, Virolainen P, Neuvonen M, Neuvonen PJ, Olkkola KT
Kustantaja: ADIS INT LTD
Julkaisuvuosi: 2011
Journal: Drugs and Aging
Tietokannassa oleva lehden nimi: DRUGS & AGING
Lehden akronyymi: DRUG AGING
Numero sarjassa: 1
Vuosikerta: 28
Numero: 1
Aloitussivu: 41
Lopetussivu: 50
Sivujen määrä: 10
ISSN: 1170-229X
DOI: https://doi.org/10.2165/11586140-000000000-00000
Tiivistelmä
Conclusions: Age is an important factor affecting the pharmacokinetics of oxycodone. Following intravenous administration of oxycodone, patients aged >70 years are expected to have, on average, 40-80% higher exposure to oxycodone than young adult patients. Because oxycodone pharmacokinetics are greatly dependent on the age of the patient, it is important to titrate the analgesic dose individually, particularly in the elderly.
Conclusions: Age is an important factor affecting the pharmacokinetics of oxycodone. Following intravenous administration of oxycodone, patients aged >70 years are expected to have, on average, 40-80% higher exposure to oxycodone than young adult patients. Because oxycodone pharmacokinetics are greatly dependent on the age of the patient, it is important to titrate the analgesic dose individually, particularly in the elderly.
Turun yliopiston Tutkimustietojärjestelmän portaali