Effect of Inhibition of Cytochrome P450 Enzymes 2D6 and 3A4 on the Pharmacokinetics of Intravenous Oxycodone A Randomized, Three-Phase, Crossover, Placebo-Controlled Study



: Gronlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Laine K, Olkkola KT

Publisher: ADIS INT LTD

: 2011

: Clinical Drug Investigation

: CLINICAL DRUG INVESTIGATION

: CLIN DRUG INVEST

: 3

: 31

: 3

: 143

: 153

: 11

: 1173-2563

DOI: https://doi.org/10.2165/11539950-000000000-00000


Conclusion: The results of this study indicate that there are no clinically relevant drug interactions with intravenous oxycodone and inhibitors of CYP2D6. If both oxidative metabolic pathways via CYP3A4 and 2D6 are inhibited the exposure to intravenous oxycodone increases substantially.



Last updated on 2024-26-11 at 23:40