A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Effect of Inhibition of Cytochrome P450 Enzymes 2D6 and 3A4 on the Pharmacokinetics of Intravenous Oxycodone A Randomized, Three-Phase, Crossover, Placebo-Controlled Study
Tekijät: Gronlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Laine K, Olkkola KT
Kustantaja: ADIS INT LTD
Julkaisuvuosi: 2011
Journal: Clinical Drug Investigation
Tietokannassa oleva lehden nimi: CLINICAL DRUG INVESTIGATION
Lehden akronyymi: CLIN DRUG INVEST
Numero sarjassa: 3
Vuosikerta: 31
Numero: 3
Aloitussivu: 143
Lopetussivu: 153
Sivujen määrä: 11
ISSN: 1173-2563
DOI: https://doi.org/10.2165/11539950-000000000-00000
Tiivistelmä
Conclusion: The results of this study indicate that there are no clinically relevant drug interactions with intravenous oxycodone and inhibitors of CYP2D6. If both oxidative metabolic pathways via CYP3A4 and 2D6 are inhibited the exposure to intravenous oxycodone increases substantially.
Conclusion: The results of this study indicate that there are no clinically relevant drug interactions with intravenous oxycodone and inhibitors of CYP2D6. If both oxidative metabolic pathways via CYP3A4 and 2D6 are inhibited the exposure to intravenous oxycodone increases substantially.
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