A1 Refereed original research article in a scientific journal

Effect of Inhibition of Cytochrome P450 Enzymes 2D6 and 3A4 on the Pharmacokinetics of Intravenous Oxycodone A Randomized, Three-Phase, Crossover, Placebo-Controlled Study



Authors: Gronlund J, Saari TI, Hagelberg NM, Neuvonen PJ, Laine K, Olkkola KT

Publisher: ADIS INT LTD

Publication year: 2011

Journal: Clinical Drug Investigation

Journal name in source: CLINICAL DRUG INVESTIGATION

Journal acronym: CLIN DRUG INVEST

Number in series: 3

Volume: 31

Issue: 3

First page : 143

Last page: 153

Number of pages: 11

ISSN: 1173-2563

DOI: https://doi.org/10.2165/11539950-000000000-00000


Abstract
Conclusion: The results of this study indicate that there are no clinically relevant drug interactions with intravenous oxycodone and inhibitors of CYP2D6. If both oxidative metabolic pathways via CYP3A4 and 2D6 are inhibited the exposure to intravenous oxycodone increases substantially.



Last updated on 2024-26-11 at 23:40