Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion



: Santio NM, Vahakoski RL, Rainio EM, Sandholm JA, Virtanen SS, Prudhomme M, Anizon F, Moreau P, Koskinen PJ

Publisher: BIOMED CENTRAL LTD

: 2010

: Molecular Cancer

: MOLECULAR CANCER

: MOL CANCER

: ARTN 279

: 9

: 13

: 1476-4598

DOI: https://doi.org/10.1186/1476-4598-9-279

: https://research.utu.fi/converis/portal/Publication/1643758


Conclusions: Altogether, our data indicate that DHPCC-9 is not only a powerful tool to investigate physiological effects of the oncogenic Pim family kinases, but also an attractive molecule for drug development to inhibit invasiveness of Pim-overexpressing cancer cells.

Last updated on 2024-26-11 at 16:15