The Effect of Water Plasticization on the Molecular Mobility and Crystallization Tendency of Amorphous Disaccharides



: Heljo VP, Nordberg A, Tenho M, Virtanen T, Jouppila K, Salonen J, Maunu SL, Juppo AM

Publisher: SPRINGER/PLENUM PUBLISHERS

: 2012

 Pharmaceutical Research

: PHARMACEUTICAL RESEARCH

: PHARM RES-DORDR

: 10

: 29

: 10

: 2684

: 2697

: 14

: 0724-8741

DOI: https://doi.org/10.1007/s11095-011-0658-4


Slow amorphous-to-crystalline transition rate is known to be important for lyoprotecting excipients when formulating a robust drug product. The physical stabilities of amorphous trehalose and melibiose even with relatively high water contents might make their use advantageous in this respect compared to sucrose and cellobiose.


amorphous, crystallization, disaccharide, mobility, water



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