A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The Effect of Water Plasticization on the Molecular Mobility and Crystallization Tendency of Amorphous Disaccharides
Tekijät: Heljo VP, Nordberg A, Tenho M, Virtanen T, Jouppila K, Salonen J, Maunu SL, Juppo AM
Kustantaja: SPRINGER/PLENUM PUBLISHERS
Julkaisuvuosi: 2012
Journal: Pharmaceutical Research
Tietokannassa oleva lehden nimi: PHARMACEUTICAL RESEARCH
Lehden akronyymi: PHARM RES-DORDR
Numero sarjassa: 10
Vuosikerta: 29
Numero: 10
Aloitussivu: 2684
Lopetussivu: 2697
Sivujen määrä: 14
ISSN: 0724-8741
DOI: https://doi.org/10.1007/s11095-011-0658-4
Tiivistelmä
Slow amorphous-to-crystalline transition rate is known to be important for lyoprotecting excipients when formulating a robust drug product. The physical stabilities of amorphous trehalose and melibiose even with relatively high water contents might make their use advantageous in this respect compared to sucrose and cellobiose.
Slow amorphous-to-crystalline transition rate is known to be important for lyoprotecting excipients when formulating a robust drug product. The physical stabilities of amorphous trehalose and melibiose even with relatively high water contents might make their use advantageous in this respect compared to sucrose and cellobiose.
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