A1 Refereed original research article in a scientific journal

The Effect of Water Plasticization on the Molecular Mobility and Crystallization Tendency of Amorphous Disaccharides



Authors: Heljo VP, Nordberg A, Tenho M, Virtanen T, Jouppila K, Salonen J, Maunu SL, Juppo AM

Publisher: SPRINGER/PLENUM PUBLISHERS

Publication year: 2012

Journal: Pharmaceutical Research

Journal name in source: PHARMACEUTICAL RESEARCH

Journal acronym: PHARM RES-DORDR

Number in series: 10

Volume: 29

Issue: 10

First page : 2684

Last page: 2697

Number of pages: 14

ISSN: 0724-8741

DOI: https://doi.org/10.1007/s11095-011-0658-4


Abstract
Slow amorphous-to-crystalline transition rate is known to be important for lyoprotecting excipients when formulating a robust drug product. The physical stabilities of amorphous trehalose and melibiose even with relatively high water contents might make their use advantageous in this respect compared to sucrose and cellobiose.



Last updated on 2024-26-11 at 10:48