Di(azacrown) conjugates of 2 '-O-methyl oligoribonucleotides as sequence-selective artificial ribonucleases



: Niittymaki T, Virta P, Ketomaki K, Lonnberg H

: 2008

Collection Symposium Series

CHEMISTRY OF NUCLEIC ACID COMPONENTS

: COLL SYMPOS SERIES

: 10

: 378

: 379

: 2

: 978-80-86241-29-6


Functionalized 2'-O-methyl oligoribonucleotides have been prepared on a solid-support by conventional phosphoramidite chemistry. Tethering of two azacrown ligands to the T-terminus of a 2'-O-methyl oligoribonucleotide increases the catalytic efficiency by more than one order of magnitude compared to the corresponding monoazacrown-derivatized oligonucleotide.



Last updated on 2025-14-10 at 10:09