B1 Non-refereed article in a scientific journal
Di(azacrown) conjugates of 2 '-O-methyl oligoribonucleotides as sequence-selective artificial ribonucleases
Authors: Niittymaki T, Virta P, Ketomaki K, Lonnberg H
Publication year: 2008
Journal:: Collection Symposium Series
Journal name in source: CHEMISTRY OF NUCLEIC ACID COMPONENTS
Journal acronym: COLL SYMPOS SERIES
Volume: 10
First page : 378
Last page: 379
Number of pages: 2
ISBN: 978-80-86241-29-6
Abstract
Functionalized 2'-O-methyl oligoribonucleotides have been prepared on a solid-support by conventional phosphoramidite chemistry. Tethering of two azacrown ligands to the T-terminus of a 2'-O-methyl oligoribonucleotide increases the catalytic efficiency by more than one order of magnitude compared to the corresponding monoazacrown-derivatized oligonucleotide.
Functionalized 2'-O-methyl oligoribonucleotides have been prepared on a solid-support by conventional phosphoramidite chemistry. Tethering of two azacrown ligands to the T-terminus of a 2'-O-methyl oligoribonucleotide increases the catalytic efficiency by more than one order of magnitude compared to the corresponding monoazacrown-derivatized oligonucleotide.
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