B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Di(azacrown) conjugates of 2 '-O-methyl oligoribonucleotides as sequence-selective artificial ribonucleases
Tekijät: Niittymaki T, Virta P, Ketomaki K, Lonnberg H
Julkaisuvuosi: 2008
Lehti:: Collection Symposium Series
Tietokannassa oleva lehden nimi: CHEMISTRY OF NUCLEIC ACID COMPONENTS
Lehden akronyymi: COLL SYMPOS SERIES
Vuosikerta: 10
Aloitussivu: 378
Lopetussivu: 379
Sivujen määrä: 2
ISBN: 978-80-86241-29-6
Tiivistelmä
Functionalized 2'-O-methyl oligoribonucleotides have been prepared on a solid-support by conventional phosphoramidite chemistry. Tethering of two azacrown ligands to the T-terminus of a 2'-O-methyl oligoribonucleotide increases the catalytic efficiency by more than one order of magnitude compared to the corresponding monoazacrown-derivatized oligonucleotide.
Functionalized 2'-O-methyl oligoribonucleotides have been prepared on a solid-support by conventional phosphoramidite chemistry. Tethering of two azacrown ligands to the T-terminus of a 2'-O-methyl oligoribonucleotide increases the catalytic efficiency by more than one order of magnitude compared to the corresponding monoazacrown-derivatized oligonucleotide.
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