Cu(2+)TerPy complexes as catalysts of the cleavage of the 5 '-cap structure of mRNA



: Maanpaa L, Taherpour S, Zhang Z, Guillaume C, Szilagy I, Maki E, Mikkola S

Publisher: TAYLOR & FRANCIS INC

: 2007

: Nucleosides, Nucleotides and Nucleic Acids

: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

: NUCLEOS NUCLEOT NUCL

: 26

: 10-12

: 1423

: 1426

: 4

: 1525-7770

DOI: https://doi.org/10.1080/15257770701539393(external)


Cu2+ TerPy is a fairly good catalyst of the cleavage of dinucleoside triphosphates, but its efficiency is not suffiecient for the use in artificial RNA cleaving enzymes. The Present work is aimed at improving the catalysis by Cu2+ TerPy with additional catalysts. Electrophilic and general acid catalysis have been studied and bifunctional catalysis have been synthesized. The most efficient catalysis was achieved with a Cu2+ Terfy-dimer.



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