A1 Refereed original research article in a scientific journal
Cu(2+)TerPy complexes as catalysts of the cleavage of the 5 '-cap structure of mRNA
Authors: Maanpaa L, Taherpour S, Zhang Z, Guillaume C, Szilagy I, Maki E, Mikkola S
Publisher: TAYLOR & FRANCIS INC
Publication year: 2007
Journal: Nucleosides, Nucleotides and Nucleic Acids
Journal name in source: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Journal acronym: NUCLEOS NUCLEOT NUCL
Volume: 26
Issue: 10-12
First page : 1423
Last page: 1426
Number of pages: 4
ISSN: 1525-7770
DOI: https://doi.org/10.1080/15257770701539393
Abstract
Cu2+ TerPy is a fairly good catalyst of the cleavage of dinucleoside triphosphates, but its efficiency is not suffiecient for the use in artificial RNA cleaving enzymes. The Present work is aimed at improving the catalysis by Cu2+ TerPy with additional catalysts. Electrophilic and general acid catalysis have been studied and bifunctional catalysis have been synthesized. The most efficient catalysis was achieved with a Cu2+ Terfy-dimer.
Cu2+ TerPy is a fairly good catalyst of the cleavage of dinucleoside triphosphates, but its efficiency is not suffiecient for the use in artificial RNA cleaving enzymes. The Present work is aimed at improving the catalysis by Cu2+ TerPy with additional catalysts. Electrophilic and general acid catalysis have been studied and bifunctional catalysis have been synthesized. The most efficient catalysis was achieved with a Cu2+ Terfy-dimer.
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