A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Cu(2+)TerPy complexes as catalysts of the cleavage of the 5 '-cap structure of mRNA
Tekijät: Maanpaa L, Taherpour S, Zhang Z, Guillaume C, Szilagy I, Maki E, Mikkola S
Kustantaja: TAYLOR & FRANCIS INC
Julkaisuvuosi: 2007
Journal: Nucleosides, Nucleotides and Nucleic Acids
Tietokannassa oleva lehden nimi: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Lehden akronyymi: NUCLEOS NUCLEOT NUCL
Vuosikerta: 26
Numero: 10-12
Aloitussivu: 1423
Lopetussivu: 1426
Sivujen määrä: 4
ISSN: 1525-7770
DOI: https://doi.org/10.1080/15257770701539393
Tiivistelmä
Cu2+ TerPy is a fairly good catalyst of the cleavage of dinucleoside triphosphates, but its efficiency is not suffiecient for the use in artificial RNA cleaving enzymes. The Present work is aimed at improving the catalysis by Cu2+ TerPy with additional catalysts. Electrophilic and general acid catalysis have been studied and bifunctional catalysis have been synthesized. The most efficient catalysis was achieved with a Cu2+ Terfy-dimer.
Cu2+ TerPy is a fairly good catalyst of the cleavage of dinucleoside triphosphates, but its efficiency is not suffiecient for the use in artificial RNA cleaving enzymes. The Present work is aimed at improving the catalysis by Cu2+ TerPy with additional catalysts. Electrophilic and general acid catalysis have been studied and bifunctional catalysis have been synthesized. The most efficient catalysis was achieved with a Cu2+ Terfy-dimer.
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