Comparison of the effects of esomeprazole and fundoplication on airway responsiveness in patients with gastro-oesophageal reflux disease



: Kiljander T, Rantanen T, Kellokumpu I, Kööbi T, Lammi L, Nieminen M, Poussa T, Ranta A, Saarelainen S, Salminen P

Publisher: WILEY-BLACKWELL

: 2013

: Clinical Respiratory Journal

: CLINICAL RESPIRATORY JOURNAL

: CLIN RESPIR J

: 3

: 7

: 3

: 281

: 287

: 7

: 1752-6981

DOI: https://doi.org/10.1111/crj.12005


Conclusions Neither esomeprazole treatment nor fundoplication diminishes airway responsiveness or exhaled NO, or improves FEV1 in patients with GORD. Improvements in respiratory symptoms and SGRQ scores after GORD treatments could be detected. However, as this was not a placebo-controlled study, the findings in these secondary endpoints should not be emphasised. ClinicalTrials.cov: NCT00994708.



Last updated on 2024-26-11 at 21:26