A1 Refereed original research article in a scientific journal
Comparison of the effects of esomeprazole and fundoplication on airway responsiveness in patients with gastro-oesophageal reflux disease
Authors: Kiljander T, Rantanen T, Kellokumpu I, Kööbi T, Lammi L, Nieminen M, Poussa T, Ranta A, Saarelainen S, Salminen P
Publisher: WILEY-BLACKWELL
Publication year: 2013
Journal: Clinical Respiratory Journal
Journal name in source: CLINICAL RESPIRATORY JOURNAL
Journal acronym: CLIN RESPIR J
Number in series: 3
Volume: 7
Issue: 3
First page : 281
Last page: 287
Number of pages: 7
ISSN: 1752-6981
DOI: https://doi.org/10.1111/crj.12005
Abstract
Conclusions Neither esomeprazole treatment nor fundoplication diminishes airway responsiveness or exhaled NO, or improves FEV1 in patients with GORD. Improvements in respiratory symptoms and SGRQ scores after GORD treatments could be detected. However, as this was not a placebo-controlled study, the findings in these secondary endpoints should not be emphasised. ClinicalTrials.cov: NCT00994708.
Conclusions Neither esomeprazole treatment nor fundoplication diminishes airway responsiveness or exhaled NO, or improves FEV1 in patients with GORD. Improvements in respiratory symptoms and SGRQ scores after GORD treatments could be detected. However, as this was not a placebo-controlled study, the findings in these secondary endpoints should not be emphasised. ClinicalTrials.cov: NCT00994708.
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