A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Comparison of the effects of esomeprazole and fundoplication on airway responsiveness in patients with gastro-oesophageal reflux disease
Tekijät: Kiljander T, Rantanen T, Kellokumpu I, Kööbi T, Lammi L, Nieminen M, Poussa T, Ranta A, Saarelainen S, Salminen P
Kustantaja: WILEY-BLACKWELL
Julkaisuvuosi: 2013
Journal: Clinical Respiratory Journal
Tietokannassa oleva lehden nimi: CLINICAL RESPIRATORY JOURNAL
Lehden akronyymi: CLIN RESPIR J
Numero sarjassa: 3
Vuosikerta: 7
Numero: 3
Aloitussivu: 281
Lopetussivu: 287
Sivujen määrä: 7
ISSN: 1752-6981
DOI: https://doi.org/10.1111/crj.12005
Tiivistelmä
Conclusions Neither esomeprazole treatment nor fundoplication diminishes airway responsiveness or exhaled NO, or improves FEV1 in patients with GORD. Improvements in respiratory symptoms and SGRQ scores after GORD treatments could be detected. However, as this was not a placebo-controlled study, the findings in these secondary endpoints should not be emphasised. ClinicalTrials.cov: NCT00994708.
Conclusions Neither esomeprazole treatment nor fundoplication diminishes airway responsiveness or exhaled NO, or improves FEV1 in patients with GORD. Improvements in respiratory symptoms and SGRQ scores after GORD treatments could be detected. However, as this was not a placebo-controlled study, the findings in these secondary endpoints should not be emphasised. ClinicalTrials.cov: NCT00994708.
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