Solid-Supported Synthesis of Glycoconjugates



: Lonnberg H

Publisher: BENTHAM SCIENCE PUBL LTD

: 2009

 Current Organic Synthesis

: CURRENT ORGANIC SYNTHESIS

: CURR ORG SYNTH

: 6

: 4

: 400

: 425

: 26

: 1570-1794

DOI: https://doi.org/10.2174/157017909789108729


Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugates have, hence, been under active development. The present paper is a review of the solid-phase protocols useful for preparation of glycoconjugates.



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