A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Solid-Supported Synthesis of Glycoconjugates
Tekijät: Lonnberg H
Kustantaja: BENTHAM SCIENCE PUBL LTD
Julkaisuvuosi: 2009
Lehti:: Current Organic Synthesis
Tietokannassa oleva lehden nimi: CURRENT ORGANIC SYNTHESIS
Lehden akronyymi: CURR ORG SYNTH
Vuosikerta: 6
Numero: 4
Aloitussivu: 400
Lopetussivu: 425
Sivujen määrä: 26
ISSN: 1570-1794
DOI: https://doi.org/10.2174/157017909789108729
Tiivistelmä
Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugates have, hence, been under active development. The present paper is a review of the solid-phase protocols useful for preparation of glycoconjugates.
Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugates have, hence, been under active development. The present paper is a review of the solid-phase protocols useful for preparation of glycoconjugates.
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