A2 Refereed review article in a scientific journal
Solid-Supported Synthesis of Glycoconjugates
Authors: Lonnberg H
Publisher: BENTHAM SCIENCE PUBL LTD
Publication year: 2009
Journal:: Current Organic Synthesis
Journal name in source: CURRENT ORGANIC SYNTHESIS
Journal acronym: CURR ORG SYNTH
Volume: 6
Issue: 4
First page : 400
Last page: 425
Number of pages: 26
ISSN: 1570-1794
DOI: https://doi.org/10.2174/157017909789108729
Abstract
Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugates have, hence, been under active development. The present paper is a review of the solid-phase protocols useful for preparation of glycoconjugates.
Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugates have, hence, been under active development. The present paper is a review of the solid-phase protocols useful for preparation of glycoconjugates.
UTU Research Portal