Johanna Hynninen
 Adjunct professor, MD, Gynecologic oncologist

  

  

  

1 of 5

  

  

  

---

• Dynamic and Ongoing De Novo L1 Retrotransposition Contributes to Genome Plasticity and Intrapatient Heterogeneity in Ovarian Cancer  (2026)  
  • Cancer Research
   Pradhan, Barun; Oikkonen, Jaana; Zhang, Kaiyang; Botto, Juan Manuel.; Eriksson, Minna R.; Sundaresan, Srividhya; Genç, Fatih; Pisanic, Thomas R.; Marin Falco, Matias; Li, Yilin; Pikkusaari, Sanna; Lavikka, Kari; Micoli, Giulia; Marchi, Giovanni; Muranen, Taru A.; Huhtinen, Kaisa; Vähärautio, Anna; Badge, Richard; Burns, Kathleen H.; Hietanen, Sakari; Hynninen, Johanna; Faulkner, Geoffrey J.; Hautaniemi, Sampsa; Kauppi, Liisa

  
  

• PATHOS: Pathology attention framework for treatment response stratification in ovarian high-grade serous carcinomas following neoadjuvant chemotherapy on H&E images  (2026)  
  • Journal of Pathology Informatics
   Miccolis, Francesca; Lovino, Marta; Lehtonen, Oskari; Hynninen, Johanna; Hautaniemi, Sampsa; Virtanen, Anni; Ficarra, Elisa

  
  

• Association of clinical and laboratory variables with risk of venous thromboembolism in high-grade serous ovarian cancer  (2025)  
  • International Journal of Gynecological Cancer
   Peippo, Maija H.; Perkonoja, Katariina; Isoviita, Veli-Matti; Hynninen, Johanna; Lassila, Riitta; Carpén, Olli

  
  

• Decoding the Genomic and Functional Landscape of Emerging Subtypes in Ovarian Cancer  (2025)  
  • Cancer Discovery
   Micoli, Giulia; Lavikka, Kari; Li, Yilin; Pirttikoski, Anna; Afenteva, Daria; Senkowski, Wojciech; Marchi, Giovanni; Vähärautio, Anna; Muranen, Taru A.; Joutsiniemi, Titta; Hietanen, Sakari; Virtanen, Anni; Wennerberg, Krister; Hynninen, Johanna; Oikkonen, Jaana; Hautaniemi, Sampsa

  
  

• Drug target proteome profiling identifies HES1-driven mitotic catastrophe in ovarian serous carcinoma  (2025)  
  • Biomedicine and Pharmacotherapy
   Bao, Jie; Pikkusaari, Sanna; Dai, Jun; Leppiniemi, Samuel; Huang, Wenjun; Yang, Weiming; Anil, Anu; Pääkkönen, Mirva; Lei, Chuqi; Mendoza-Ortiz, Eva Daniela; Karagöz, Ezgi; Eriksson, Johanna; Li, Min; Hynninen, Johanna; Kauko, Otto; Färkkilä, Anniina; Vähärautio, Anna; Hautaniemi, Sampsa; Kauppi, Liisa; Tang, Jing

  
  

• MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer  (2025)  
  • Scientific Reports
   Afrin Ruma, Shamima; Vinod, Rufus; Jain, Shruti; Huhtinen, Kaisa; Hynninen, Johanna; Leivo, Janne; Pettersson, Kim; Sundfeldt, Karin; Gidwani, Kamlesh

  
  

• Multi-omics analysis reveals the attenuation of the interferon pathway as a driver of chemo-refractory ovarian cancer  (2025)  
  • Cell Reports Medicine
   Afenteva, Daria; Yu, Rong; Rajavuori, Anna; Salvadores, Marina; Launonen, Inga-Maria; Lavikka, Kari; Zhang, Kaiyang; Pirttikoski, Anna; Marchi, Giovanni; Jamalzadeh, Sanaz; Isoviita, Veli-Matti; Li, Yilin; Micoli, Giulia; Erkan, Erdogan Pekcan; Falco, Matias M.; Ungureanu, Daniela; Lahtinen, Alexandra; Oikkonen, Jaana; Hietanen, Sakari; Vähärautio, Anna; Sur, Inderpreet; Virtanen, Anni; Färkkilä, Anniina; Hynninen, Johanna; Muranen, Taru A.; Taipale, Jussi; Hautaniemi, Sampsa

  
  

• Novel glycovariant biomarkers of CA125 and CA15-3 and their diagnostic performance across histotypes of ovarian cancer: A multi-cohort study in Sweden and Finland  (2025)  
  • European Journal of Obstetrics and Gynecology and Reproductive Biology
   Roos Alexander, Hanna; Jain, Shruti; Gidwani, Kamlesh; Ulfenborg, Benjamin; Ottander, Ulrika; Lundin, Eva; Hynninen, Johanna; Afrin Ruma, Shamima; Huhtinen, Kaisa; Sundfeldt, Karin; Pettersson, Kim; Idahl, Annika

  
  

• A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells  (2024)  
  • Science Advances
   Bulanova, Daria; Akimov, Yevhen; Senkowski, Wojciech; Oikkonen, Jaana; Gall-Mas, Laura; Timonen, Sanna; Elmadani, Manar; Hynninen, Johanna; Hautaniemi, Sampsa; Aittokallio, Tero; Wennerberg, Krister

  
  

• Bexmarilimab Activates Human Tumor-Associated Macrophages to Support Adaptive Immune Responses in Interferon-Poor Immune Microenvironments  (2024)  
  • Cancer Immunology Research
   Rannikko, Jenna H.; Bono, Petri; Hynninen, Johanna; Hollmén, Maija

  
  

• Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer  (2024)  
  • Cancer Cell
   Launonen, Inga-Maria; Niemiec, Iga; Hincapié-Otero, María; Erkan, Pekcan Erdogan; Junquera, Ada; Afenteva, Daria; Falco, Matias M.; Liang, Zhihan; Salko, Matilda; Chamchougia, Foteini; Szabo, Angela; Perez-Villatoro, Fernando; Li, Yilin; Micoli, Giulia; Nagaraj, Ashwini; Haltia, Ulla-Maija; Kahelin, Essi; Oikkonen, Jaana; Hynninen, Johanna; Virtanen, Anni; Nirmal, Ajit J.; Vallius, Tuulia; Hautaniemi, Sampsa; Sorger, Peter K.; Vähärautio, Anna; Färkkilä, Anniina

  
  

• Deciphering cancer genomes with GenomeSpy : a grammar-based visualization toolkit  (2024)  
  • GigaScience
   Lavikka, Kari; Oikkonen, Jaana; Li, Yilin; Muranen, Taru; Micoli, Giulia; Marchi, Giovanni; Lahtinen, Alexandra; Huhtinen, Kaisa; Lehtonen, Rainer; Hietanen, Sakari; Hynninen, Johanna; Virtanen, Anni; Hautaniemi, Sampsa

  
  

• Extensive mutational ctDNA profiles reflect High-grade serous cancer tumors and reveal emerging mutations at recurrence  (2024)  
  • Translational Oncology
   Marchi, Giovanni; Rajavuori, Anna; Nguyen, Mai T. N.; Huhtinen, Kaisa; Oksa, Sinikka; Hietanen, Sakari; Hautaniemi, Sampsa; Hynninen, Johanna; Oikkonen, Jaana

  
  

• Genome-wide quantification of copy-number aberration impact on gene expression in ovarian high-grade serous carcinoma  (2024)  
  • BMC Cancer
   Jamalzadeh, Sanaz; Dai, Jun; Lavikka, Kari; Li, Yilin; Jiang, Jing; Huhtinen, Kaisa; Virtanen, Anni; Oikkonen, Jaana; Hietanen, Sakari; Hynninen, Johanna; Vähärautio, Anna; Häkkinen, Antti; Hautaniemi, Sampsa

  
  

• HRD related signature 3 predicts clinical outcome in advanced tubo-ovarian high-grade serous carcinoma  (2024)  
  • Gynecologic Oncology
   Koskela, Heidi; Li, Yilin; Joutsiniemi, Titta; Muranen, Taru; Isoviita, Veli-Matti; Huhtinen, Kaisa; Micoli, Giulia; Lavikka, Kari; Marchi, Giovanni; Hietanen, Sakari; Virtanen, Anni; Hautaniemi, Sampsa; Oikkonen, Jaana; Hynninen, Johanna

  
  

• Is it safe to operate selected low-risk endometrial cancer patients in secondary hospitals?  (2024)  
  • EJSO - European Journal of Surgical Oncology
   Narva, Sara; Polo-Kantola, Päivi; Oksa, Sinikka; Kallio, Johanna; Huvila, Jutta; Rissanen, Tiia; Hynninen, Johanna; Hietanen, Sakari; Joutsiniemi, Titta

  
  

• Kohdunrungon syövän diagnostiikka  (2024)  Syöpäsairaudet Puistola, Ulla; Mäenpää, Johanna; Staff, Synnöve; Hynninen, Johanna

  
  

• Kohdunrungon syövän hoito  (2024)  Syöpäsairaudet Puistola, Ulla; Mäenpää, Johanna; Lindholm, Paula; Staff, Synnöve; Hynninen, Johanna

  
  

• Kohdunrungon syövän yleisyys, vaaratekijät ja esiasteet  (2024)  Syöpäsairaudet Puistola, Ulla; Mäenpää, Johanna; Staff, Synnöve; Hynninen, Johanna

  
  

• Kohtusarkoomat  (2024)  Syöpäsairaudet Puistola, Ulla; Mäenpää, Johanna; Staff, Synnöve; Hynninen, Johanna