Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0001-5648-4532 |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- A systematic evaluation of normalization methods in quantitative label-free proteomics (2018)
- Briefings in Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Early fecal microbiota composition in children who later develop celiac disease and associated autoimmunity (2018)
- Scandinavian Journal of Gastroenterology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes (2018)
- Diabetologia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Hydroxysteroid (17 beta) dehydrogenase 13 deficiency triggers hepatic steatosis and inflammation in mice (2018)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer (2018)
- Endocrine-Related Cancer
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - PASI: A novel pathway method to identify delicate group effects (2018)
- PLoS ONE
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Phosphonormalizer: an R package for normalization of MS-based label-free phosphoproteomics (2018)
- Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis (2018)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - SimPhospho: a software tool enabling confident phosphosite assignment (2018)
- Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women (2018)
- Frontiers in Microbiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Tekonivelen sijoiltaanmenoon myötävaikuttavat tekijät lonkan tekonivelleikkauksen jälkeen (2018)
- Suomen ortopedia ja traumatologia
(D1 Artikkeli ammattilehdessä) - Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells (2018)
- Cell Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Accurate detection of differential expression and splicing using low-level features (2017)
- Methods in Molecular Biology
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - A DREAM Challenge to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer (2017)
- JCO Clinical Cancer Informatics
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - A predictive model of overall survival in patients with metastatic castration-resistant prostate cancer (2017)
- F1000Research
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Assessing the utilization of radiotherapy near end of life at a Finnish University Hospital: a retrospective cohort study (2017)
- Acta Oncologica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Comparison of methods to detect differentially expressed genes between single-cell populations (2017)
- Briefings in Bioinformatics
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - End-of-life chemotherapy use at a Finnish university hospital: a retrospective cohort study. (2017)
- Acta Oncologica
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Enhanced differential expression statistics for data-independent acquisition proteomics (2017)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma (2017)
- Cancer and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )