Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID-tunniste: https://orcid.org/0000-0001-5648-4532 |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- Adaptive sequence alignment for metagenomic data analysis (2025)
- Computers in Biology and Medicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Metaproteomics Beyond Databases: Addressing the Challenges and Potentials of De Novo Sequencing (2025)
- Proteomics
(B1 Vertaisarvioitu muu artikkeli (esim. pääkirjoitus, letter, comment) tieteellisessä lehdessä) - Proteomic profiling reveals alterations in metabolic and cellular pathways in severe obesity and following metabolic bariatric surgery (2025)
- American Journal of Physiology : Endocrinology and Metabolism
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease (2025)
- Diabetologia
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - A proximal enhancer regulates RORA expression during early human Th17 cell differentiation (2024)
- Clinical Immunology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Deep Learning Enables Automatic Detection of Joint Damage Progression in Rheumatoid Arthritis-Model Development and External Validation (2024)
- Rheumatology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Differences in Gut Microbiota Profiles and Microbiota Steroid Hormone Biosynthesis in Men with and Without Prostate Cancer (2024)
- European Urology Open Science
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis (2024)
- FASEB Journal
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies (2024)
- Nature Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - ECCB2024: The 23rd European Conference on Computational Biology (2024)
- Bioinformatics
(B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä ) - Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells (2024)
- Reproductive Sciences
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Inferring Tree-Shaped Single-Cell Trajectories with Totem (2024)
- Methods in Molecular Biology
(A3 Vertaisarvioitu kirjan tai muun kokoomateoksen osa) - Integrative analysis of endometriosis and adenomyosis through single-cell transcriptomics (2024)
- Human Reproduction
(Abstrakti) - Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA (2024)
- Proceedings of the National Academy of Sciences of the United States of America
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Multi-omics analysis reveals drivers of loss of β-cell function after newly diagnosed autoimmune type 1 diabetes : An INNODIA multicenter study (2024)
- Diabetes/Metabolism Research and Reviews
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Phenotypic profiling of human induced regulatory T cells at early differentiation : insights into distinct immunosuppressive potential (2024)
- Cellular and Molecular Life Sciences
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Prediction of Early Adverse Events After THA : A Comparison of Different Machine-Learning Strategies Based on 262,356 Observations From the Nordic Arthroplasty Register Association (NARA) Dataset (2024)
- ACR open rheumatology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study (2024)
- EBioMedicine
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Proteomics screening after pediatric allogenic hematopoietic stem cell transplantation reveals an association between increased expression of inhibitory receptor FCRL6 on γδ T cells and cytomegalovirus reactivation (2024)
- Immunology and Cell Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - RUNX transcription factors are essential in maintaining epididymal epithelial differentiation (2024)
- Cellular and Molecular Life Sciences
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )