Laura Elo
laura.elo@utu.fi +358 29 450 2090 +358 50 468 0795 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0001-5648-4532 |
Computational biomedicine, medical bioinformatics, data science, machine learning, artificial intelligence, biomarkers, computational systems immunology
Laura Elo is Professor of Computational Medicine and Head of Medical Bioinformatics Centre at University of Turku, Finland. She received PhD in Applied Mathematics in 2007 and became Adjunct Professor in Biomathematics in 2011. After postdoctoral research in molecular immunology and computational systems biology, she received JDRF Career Development Award from US and established herself as independent group leader. In 2014 she became Research Director and in 2016 Vice Director of Turku Bioscience. She has published >180 research articles and >20 software packages and led several research projects (e.g. ERC).
We develop computational methods and models for transforming large-scale molecular and clinical datasets to biomedical knowledge. A specific focus is on analyzing and interpreting data generated by modern high-throughput biotechnologies and other digital health data in a robust and reproducible manner. Using statistical modelling and advanced machine learning techniques, we have, for instance, identified early markers for type 1 diabetes and developed several powerful computational models for predicting disease and treatment risks. The ultimate goal is to improve the diagnosis, prognosis and treatment of complex diseases in close collaboration with experimental and clinical research groups. In our ongoing studies, we focus on development of robust computational tools for proteome, epigenome, and multi-modal single-cell data analysis; artificial intelligence in the analysis of digital health data for early prediction of disease and treatment risks; and computational systems immunology to study human T cell development and immune-mediated diseases. For more information, visit our website: https://elolab.utu.fi
Modern Biotechnologies and Bioinformatics; Bioinformatics in Drug Discovery; Systems biology; AI in Diagnostics, Drug Discovery and Imaging; Bioinformatics Journal Club
Training of MSc and PhD students and postdoctoral fellows
- Stable Iterative Variable Selection (2021)
- Bioinformatics
(A1 Refereed original research article in a scientific journal) - Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis (2021)
- Sci
(A1 Refereed original research article in a scientific journal) - A carbohydrate-active enzyme (CAZy) profile links successful metabolic specialization of Prevotella to its abundance in gut microbiota (2020)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+T Lymphocyte Signature (2020)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - CIP2A Constrains Th17 Differentiation by Modulating STAT3 Signaling (2020)
- iScience
(A1 Refereed original research article in a scientific journal) - Critical evaluation of the subcutaneous engraftments of hormone naïve primary prostate cancer (2020)
- Translational andrology and urology
(A1 Refereed original research article in a scientific journal) - Data-Independent Acquisition Mass Spectrometry in Metaproteomics of Gut Microbiota—Implementation and Computational Analysis (2020)
- Journal of Proteome Research
(A1 Refereed original research article in a scientific journal) - Easy-to-use tool for evaluating the elevated acute kidney injury risk against reduced cardiovascular disease risk during intensive blood pressure control (2020)
- Journal of Hypertension
(A1 Refereed original research article in a scientific journal) - Histone deacetylases 1 and 2 restrain CD4(+) cytotoxic T lymphocyte differentiation (2020)
- JCI Insight
(A1 Refereed original research article in a scientific journal) - Integrative omics approaches provide biological and clinical insights: examples from mitochondrial diseases (2020)
- Journal of Clinical Investigation
(A2 Refereed review article in a scientific journal ) - Likelihood contrasts: a machine learning algorithm for binary classification of longitudinal data (2020)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - MASTL promotes cell contractility and motility through kinase-independent signaling (2020)
- Journal of Cell Biology
(A1 Refereed original research article in a scientific journal) - Posterior approach, fracture diagnosis, and American Society of Anesthesiology class III-IV are associated with increased risk of revision for dislocation after total hip arthroplasty: An analysis of 33,337 operations from the Finnish Arthroplasty Register (2020)
- Scandinavian Journal of Surgery
(A1 Refereed original research article in a scientific journal) - Predicting Skeletal Muscle and Whole-Body Insulin Sensitivity Using NMR-Metabolomic Profiling (2020)
- Journal of the Endocrine Society
(A1 Refereed original research article in a scientific journal) - Protein interactome of the Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) in Th17 cells (2020)
- Current Research in Immunology
(A1 Refereed original research article in a scientific journal) - Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2 (2020)
- FASEB Journal
(A1 Refereed original research article in a scientific journal) - Reproducibility-optimized detection of differential DNA methylation (2020)
- Epigenomics
(A1 Refereed original research article in a scientific journal) - Transcriptomic responses to hypoxia in endometrial and decidual stromal cells (2020)
- Reproduction
(A1 Refereed original research article in a scientific journal) - A Data Analysis Protocol for Quantitative Data-Independent Acquisition Proteomics. (2019)
- Methods in Molecular Biology
(A3 Refereed book chapter or chapter in a compilation book) - Adverse Events During Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer (2019)
- Bladder Cancer
(A1 Refereed original research article in a scientific journal)