A1 Refereed original research article in a scientific journal
An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood
Authors: Keskitalo Anniina, Munukka Eveliina, Aatsinki Anna, Saleem Wisam, Kartiosuo Noora, Lahti Leo, Huovinen Pentti, Elo Laura L, Pietilä Sami, Rovio Suvi P, Niinikoski Harri, Viikari Jorma, Rönnemaa Tapani, Lagström Hanna, Jula Antti, Raitakari Olli, Pahkala Katja
Publisher: MDPI
Publication year: 2022
Journal: Nutrients
Journal name in source: NUTRIENTS
Journal acronym: NUTRIENTS
Article number: 2667
Volume: 14
Issue: 13
Number of pages: 17
DOI: https://doi.org/10.3390/nu14132667
Web address : https://www.mdpi.com/2072-6643/14/13/2667
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/175931508
The randomized controlled Special Turku Coronary Risk Factor Intervention Project (STRIP) has completed a 20-year infancy-onset dietary counselling intervention to reduce exposure to atherosclerotic cardiovascular disease risk factors via promotion of a heart-healthy diet. The counselling on, e.g., low intake of saturated fat and cholesterol and promotion of fruit, vegetable, and whole-grain consumption has affected the dietary characteristics of the intervention participants. By leveraging this unique cohort, we further investigated whether this long-term dietary intervention affected the gut microbiota bacterial profile six years after the intervention ceased. Our sub-study comprised 357 individuals aged 26 years (intervention n = 174, control n = 183), whose gut microbiota were profiled using 16S rRNA amplicon sequencing. We observed no differences in microbiota profiles between the intervention and control groups. However, out of the 77 detected microbial genera, the Veillonella genus was more abundant in the intervention group compared to the controls (log(2) fold-change 1.58, p < 0.001) after adjusting for multiple comparison. In addition, an association between the study group and overall gut microbiota profile was found only in males. The subtle differences in gut microbiota abundances observed in this unique intervention setting suggest that long-term dietary counselling reflecting dietary guidelines may be associated with alterations in gut microbiota.
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