Mikko Metsä-Ketelä
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mianme@utu.fi
+358 29 450 4786
+358 50 436 6523
Tykistökatu 6
Turku
ABE
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Asiantuntijuusalueet
Natural products; Streptomyces; biosynthesis
Tutkimus
http://abelab.utu.fi
Opetus
Molecular Biology
Structural Biology
Julkaisut
- Facultative predation expands the ecological repertoire of Streptomyces (2026) Yamada, Keith; Koroleva, Arina; Tirkkonen, Heli; Siitonen, Vilja; Laughlin, Mitchell; Moglia, Amanda; Matroodi, Soheila; Akhgari, Amir; Mazurier, Guillaume; Niemi, Jarmo; Metsä-Ketelä, Mikko
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Functional Plasticity of Methyltransferases in Anthracycline Biosynthesis: A Single Residue Reversal between Decarboxylation and Hydroxylation (2026) Sang, Moli; Yang, Qingyu; Guo, Jiawei; Feng, Peiyuan; Gao, Yu; Ma, Wencheng; Li, Shengying; Metsä-Ketelä, Mikko; Zhang, Wei
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA (2026) Koroleva, Arina; Artukka, Erika; Yamada, Keith; Newmister, Sean A.; Harte, Ralph J.; Boesger, Hannah; Londen, Mikael; Sanders, Jacob N.; Tirkkonen, Heli; Kannisto, Matti; Kuin, Rosan C. M.; Hulst, Mandy; Wang, Rongbin; Leskinen, Ester; Barillec, Morgane; Niemi, Jarmo; van Wezel, Gilles P.; Neefjes, Jacques; Nybo, S. Eric; Houk, Kendall N.; Sherman, David H.; Kim, Robbert Q.; Metsä-Ketelä, Mikko
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration (2025) Zdouc, Mitja M.; Blin, Kai; Louwen, Nico L.L.; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D.; Bailey, Constance B.; Barra, Lena; Booth, Thomas J.; Bozhüyük, Kenan A.J.; Cediel-Becerra, José D.D.; Charlop-Powers, Zachary; Chevrette, Marc G.; Chooi, Yit Heng; D’Agostino, Paul M.; de Rond, Tristan; Del Pup, Elena; Duncan, Katherine R.; Gu, Wenjia; Hanif, Novriyandi; Helfrich, Eric J.N.; Jenner, Matthew; Katsuyama, Yohei; Korenskaia, Aleksandra; Krug, Daniel; Libis, Vincent; Lund, George A.; Mantri, Shrikant; Morgan, Kalindi D.; Owen, Charlotte; Phan, Chin-Soon; Philmus, Benjamin; Reitz, Zachary L.; Robinson, Serina L.; Singh, Kumar Saurabh; Teufel, Robin; Tong, Yaojun; Tugizimana, Fidele; Ulanova, Dana; Winter, Jaclyn M.; Aguilar, César; Akiyama, Daniel Y.; Al-Salihi, Suhad A.A.; Alanjary, Mohammad; Alberti, Fabrizio; Aleti, Gajender; Alharthi, Shumukh A.; Rojo, Mariela Y. Arias; Arishi, Amr A.; Augustijn, Hannah E.; Avalon, Nicole E.; Avelar-Rivas, J. Abraham; Axt, Kyle K.; Barbieri, Hellen B.; Barbosa, Julio Cesar J.; Barboza Segato, Lucas Gabriel; Barrett, Susanna E.; Baunach, Martin; Beemelmanns, Christine; Beqaj, Dardan; Berger, Tim; Bernaldo-Agüero, Jordan; Bettenbühl, Sandra M.; Bielinski, Vincent A.; Biermann, Friederike; Borges, Ricardo M.; Borriss, Rainer; Breitenbach, Milena; Bretscher, Kevin M.; Brigham, Michael W.; Buedenbender, Larissa; Bulcock, Brodie W.; Cano-Prieto, Carolina; Capela, João; Carrion, Victor J.; Carter, Riley S.; Castelo-Branco, Raquel; Castro-Falcón, Gabriel; Chagas, Fernanda O.; Charria-Girón, Esteban; Chaudhri, Ayesha Ahmed; Chaudhry, Vasvi; Choi, Hyukjae; Choi, Yukyung; Choupannejad, Roya; Chromy, Jakub; Donahey, Melinda S. Chue; Collemare, Jérôme; Connolly, Jack A.; Creamer, Kaitlin E.; Crüsemann, Max; Cruz, Andres Arredondo; Cumsille, Andres; Dallery, Jean-Felix; Damas-Ramos, Luis Caleb; Damiani, Tito; de Kruijff, Martinus; Martín, Belén Delgado; Sala, Gerardo Della; Dillen, Jelle; Doering, Drew T.; Dommaraju, Shravan R.; Durusu, Suhan; Egbert, Susan; Ellerhorst, Mark; Faussurier, Baptiste; Fetter, Artem; Feuermann, Marc; Fewer, David P.; Foldi, Jonathan; Frediansyah, Andri; Garza, Erin A.; Gavriilidou, Athina; Gentile, Andrea; Gerke, Jennifer; Gerstmans, Hans; Gomez-Escribano, Juan Pablo; González-Salazar, Luz A.; Grayson, Natalie E.; Greco, Claudio; Gomez, Juan E. Gris; Guerra, Sebastian; Flores, Shaday Guerrero; Gurevich, Alexey; Gutiérrez-García, Karina; Hart, Lauren; Haslinger, Kristina; He, Beibei; Hebra, Teo; Hemmann, Jethro L.; Hindra, Hindra; Höing, Lars; Holland, Darren C.; Holme, Jonathan E.; Horch, Therese; Hrab, Pavlo; Hu, Jie; Huynh, Thanh-Hau; Hwang, Ji-Yeon; Iacovelli, Riccardo; Iftime, Dumitrita; Iorio, Marianna; Jayachandran, Sidharth; Jeong, Eunah; Jing, Jiayi; Jung, Jung J.; Kakumu, Yuya; Kalkreuter, Edward; Kang, Kyo Bin; Kang, Sangwook; Kim, Wonyong; Kim, Geum Jin; Kim, Hyunwoo; Kim, Hyun Uk; Klapper, Martin; Koetsier, Robert A.; Kollten, Cassandra; Kovács, Ákos T.; Kriukova, Yelyzaveta; Kubach, Noel; Kunjapur, Aditya M.; Kushnareva, Aleksandra K.; Kust, Andreja; Lamber, Jessica; Larralde, Martin; Larsen, Niels J.; Launay, Adrien P.; Le, Ngoc-Thao-Hien; Lebeer, Sarah; Lee, Byung Tae; Lee, Kyungha; Lev, Katherine L.; Li, Shu-Ming; Li, Yong-Xin; Licona-Cassani, Cuauhtémoc; Lien, Annette; Liu, Jing; Lopez, Julius Adam V.; Machushynets, Nataliia V.; Macias, Marla I.; Mahmud, Taifo; Maleckis, Matiss; Martinez-Martinez, Añadir Maharai; Mast, Yvonne; Maximo, Marina F.; McBride, Christina M.; McLellan, Rose M.; Bhatt, Khyati Mehta; Melkonian, Chrats; Merrild, Aske; Metsä-Ketelä, Mikko; Mitchell, Douglas A.; Müller, Alison V.; Nguyen, Giang-Son; Nguyen, Hera T.; Niedermeyer, Timo H.J.; O’Hare, Julia H.; Ossowicki, Adam; Ostash, Bohdan O.; Otani, Hiroshi; Padva, Leo; Paliyal, Sunaina; Pan, Xinya; Panghal, Mohit; Parade, Dana S.; Park, Jiyoon; Parra, Jonathan; Rubio, Marcos Pedraza; Pham, Huong T.; Pidot, Sacha J.; Piel, Jörn; Pourmohsenin, Bita; Rakhmanov, Malik; Ramesh, Sangeetha; Rasmussen, Michelle H.; Rego, Adriana; Reher, Raphael; Rice, Andrew J.; Rigolet, Augustin; Romero-Otero, Adriana; Rosas-Becerra, Luis Rodrigo; Rosiles, Pablo Y.; Rutz, Adriano; Ryu, Byeol; Sahadeo, Libby-Ann; Saldanha, Murrel; Salvi, Luca; Sánchez-Carvajal, Eduardo; Santos-Medellin, Christian; Sbaraini, Nicolau; Schoellhorn, Sydney M.; Schumm, Clemens; Sehnal, Ludek; Selem, Nelly; Shah, Anjali D.; Shishido, Tania K.; Sieber, Simon; Silviani, Velina; Singh, Garima; Singh, Hemant; Sokolova, Nika; Sonnenschein, Eva C.; Sosio, Margherita; Sowa, Sven T.; Steffen, Karin; Stegmann, Evi; Streiff, Alena B.; Strüder, Alena; Surup, Frank; Svenningsen, Tiziana; Sweeney, Douglas; Szenei, Judit; Tagirdzhanov, Azat; Tan, Bin; Tarnowski, Matthew J.; Terlouw, Barbara R.; Rey, Thomas; Thome, Nicola U.; Torres Ortega, Laura Rosina; Tørring, Thomas; Trindade, Marla; Truman, Andrew W.; Tvilum, Marie; Udwary, Daniel W.; Ulbricht, Christoph; Vader, Lisa; van Wezel, Gilles P.; Walmsley, Max; Warnasinghe, Randika; Weddeling, Heiner G.; Weir, Angus N.M.; Williams, Katherine; Williams, Sam E.; Witte, Thomas E.; Rocca, Steffaney M. Wood; Yamada, Keith; Yang, Dong; Yang, Dongsoo; Yu, Jingwei; Zhou, Zhenyi; Ziemert, Nadine; Zimmer, Lukas; Zimmermann, Alina; Zimmermann, Christian; van der Hooft, Justin J.J.; Linington, Roger G.; Weber, Tilmann; Medema, Marnix H.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Three-Enzyme Cascade Catalyzes Conversion of Auramycinone to Resomycin in Chartreusin Biosynthesis (2025) Niemczura, Magdalena; Nuutila, Aleksi; Wang, Rongbin; Rauhanen, Katariina; Nybo, S. Eric; Metsä-Ketelä, Mikko
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- ActVI-ORFA directs metabolic flux towards actinorhodin by preventing intermediate degradation (2024) Zhu, Xuechen; Wang, Rongbin; Siitonen, Vilja; Vuksanovic, Nemanja; Silvaggi, Nicholas R.; Melançon III, Charles E.; Metsä-Ketelä, Mikko
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Divergence of Classical and C-Ring-Cleaved Angucyclines : Elucidation of Early Tailoring Steps in Lugdunomycin and Thioangucycline Biosynthesis (2024) Nuutila, Aleksi; Xiao, Xiansha; van der Heul, Helga U.; van Wezel, Gilles P.; Dinis, Pedro; Elsayed, Somayah S.; Metsä-Ketelä, Mikko
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Diverse Combinatorial Biosynthesis Strategies for C-H Functionalization of Anthracyclinones (2024) Wang, Rongbin; Nji Wandi, Benjamin; Schwartz, Nora; Hecht, Jacob; Ponomareva, Larissa; Paige, Kendall; West, Alexis; Desanti, Kathryn; Nguyen, Jennifer; Niemi, Jarmo; Thorson, Jon S.; Shaaban, Khaled A.; Metsä-Ketelä, Mikko; Nybo, S. Eric
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Mechanism of Two-Component Mono-Oxygenases Involved in Anthracycline 1-Hydroxylation (2024) Wandi, Benjamin Nji; Dinis, Pedro; Siitonen, Vilja; Schneider, Gunter; Schnell, Robert; Metsä-Ketelä, Mikko
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
- Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines (2024)
- Frontiers in Bioengineering and Biotechnology
Hulst, Mandy B.; Zhang, Le; van der Heul, Helga U.; Du, Chao; Elsayed, Somayah S.; Koroleva, Arina; Grocholski, Thadee; Wander, Dennis P. A.; Metsä-Ketelä, Mikko; Neefjes, Jacques J. C.; van Wezel, Gilles P.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )
