Mikko Metsä-Ketelä

- Professor,
Biochemistry (Department of Life Technologies)

mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku

ABE

Areas of expertise

Natural products; Streptomyces; biosynthesis

Research

http://abelab.utu.fi

Teaching

Molecular Biology

Structural Biology

Publications

6 of 9

Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family (2014)
- FEBS Journal
Thapa K, Oja T, Metsä-Ketelä M
(A1 Refereed original research article in a scientific journal)
Structure-Based Engineering of Angucyclinone 6-Ketoreductases. (2014)
- Chemistry and Biology
Patrikainen, Niiranen, Thapa, Paananen, Tähtinen, Mäntsälä, Niemi, Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Biosynthesis of pyranonaphthoquinone polyketides reveals diverse strategies for enzymatic carbon-carbon bond formation (2013)
- Current Opinion in Chemical Biology
Metsa-Ketela M, Oja T, Taguchi T, Okamoto S, Ichinose K
(A1 Refereed original research article in a scientific journal)
Biosynthetic Conclusions from the Functional Dissection of Oxygenases for Biosynthesis of Actinorhodin and Related Streptomyces Antibiotics (2013)
- Chemistry and Biology
Taguchi T, Yabe M, Odaki H, Shinozaki M, Metsa-Ketela M, Arai T, Okamoto S, Ichinose K
(A1 Refereed original research article in a scientific journal)
Chemoenzymatic Synthesis of Novel C-Ribosylated Naphthoquinones (2013)
- ACS Chemical Biology
Bastian Blauenburg, Terhi Oja, Karel D Klika, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Structural and Functional Analysis of Angucycline C-6 Ketoreductase LanV Involved in Landomycin Biosynthesis (2013)
- Biochemistry
Pasi Paananen, Pekka Patrikainen, Pauli Kallio, Pekka Mäntsälä, Jarmo Niemi, Laila Niiranen, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway (2013)
- Proceedings of the National Academy of Sciences of the United States of America
Terhi Oja, Laila Niiranen, Tatyana Sandalova, Karel D Klika, Jarmo Niemi, Pekka Mäntsälä, Gunter Schneider, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Synthetic Remodeling of the Chartreusin Pathway to Tune Antiproliferative and Antibacterial Activities (2013) Ueberschaar N, Xu ZL, Scherlach K, Metsa-Ketela M, Bretschneider T, Dahse HM, Gorls H, Hertweck C
(A1 Refereed original research article in a scientific journal)
Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE (2013)
- Biochemistry
Kallio P, Patrikainen P, Belogurov GA, Mantsala P, Yang KQ, Niemi J, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)
Alnumycins A2 and A3: new inverse-epimeric pairs stereoisomeric to alnumycin A1 (2012)
- Tetrahedron: Asymmetry
Oja T, Tahtinen P, Dreiack N, Mantsala P, Niemi J, Metsa-Ketela M, Klika KD
(A1 Refereed original research article in a scientific journal)