Mikko Metsä-Ketelä

- Professor,
Biochemistry (Department of Life Technologies)

mianme@utu.fi

+358 29 450 4786

+358 50 436 6523

Tykistökatu 6

Turku

ABE

Areas of expertise

Natural products; Streptomyces; biosynthesis

Research

http://abelab.utu.fi

Teaching

Molecular Biology

Structural Biology

Publications

2 of 4

Differential regulation of undecylprodigiosin biosynthesis in the yeast-scavenging Streptomyces strain MBK6 (2021)
- FEMS Microbiology Letters
Baral Bikash, Siitonen Vilja, Laughlin Mitchell, Yamada Keith, Ilomäki Mikael, Metsä-Ketelä Mikko, Niemi Jarmo
(A1 Refereed original research article in a scientific journal)
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products (2021)
- ACS Chemical Biology
Ahmed Muhammad N., Wahlsten Matti, Jokela Jouni, Nees Matthias, Stenman Ulf-Håkan, Alvarenga Danillo O., Strandin Tomas, Sivonen Kaarina, Poso Antti, Permi Perttu, Metsä-Ketelä Mikko, Koistinen Hannu, Fewer David P.
(A1 Refereed original research article in a scientific journal)
The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases (2021)
- Nature Communications
Mäkinen Janne J, Shin Yeonoh, Vieras Eeva, Virta Pasi, Metsä-Ketelä Mikko, Murakami Katsuhiko S, Belogurov Georgiy A
(A1 Refereed original research article in a scientific journal)
Evolution‐Guided Engineering of Non‐Heme Iron Enzymes Involved in Nogalamycin Biosynthesis (2020)
- FEBS Journal
Benjamin Nji Wandi, Vilja Siitonen, Pedro Dinis, Vladimir Vukic, Tiina A. Salminen, Mikko Metsä‐Ketelä
(A1 Refereed original research article in a scientific journal)
Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway (2020)
- ACS Chemical Biology
Xiansha Xiao, Somayah Elsayed, Changsheng Wu, Helga van der Heul, Mikko Metsä-Ketelä, Chao Du, Andrea Prota, Chun-Chi Chen, Weidong Liu, Rey-Ting Guo, Jan Pieter Abrahams, Gilles P. van Wezel
(A1 Refereed original research article in a scientific journal)
Genotyping-Guided Discovery of Persiamycin A From Sponge-Associated Halophilic Streptomonospora sp. PA3 (2020)
- Frontiers in Microbiology
Soheila Matroodi, Vilja Siitonen, Bikash Baral, Keith Yamada, Amir Akhgari, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Pathway engineering of anthracyclines: Blazing trails in natural product glycodiversification (2020)
- Journal of Organic Chemistry
Katelyn V. Brown, Benjamin Nji Wandi, Mikko Metsä-Ketelä, S. Eric Nybo
(A2 Refereed review article in a scientific journal )
Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis (2020)
- Acta Crystallographica Section F: Structural Biology Communications
N. Vuksanovic, X. Zhu, D.A. Serrano, V. Siitonen, M. Metsä-Ketelä, C.E. Melancon III, N.R. Silvaggi
(A1 Refereed original research article in a scientific journal)
The Rieske Oxygenase SnoT Catalyzes 2''-Hydroxylation of L-Rhodosamine in Nogalamycin Biosynthesis (2020)
- ChemBioChem
Nji Wandi Benjamin, Siitonen Vilja, Palmu Kaisa, Metsä-Ketelä Mikko
(A1 Refereed original research article in a scientific journal)
A pharmaceutical model for the molecular evolution of microbial natural products (2019)
- FEBS Journal
David P. Fewer, Mikko Metsä‐Ketelä
(A2 Refereed review article in a scientific journal )
Characterization and overproduction of cell-associated cholesterol oxidase ChoD from Streptomyces lavendulae YAKB-15 (2019)
- Scientific Reports
Keith Yamada, Arina Koroleva, Mitchell Laughlin, Niko Oksanen, Amir Akhgari,
Vera Safronova, Elena Yakovleva, Vera Kolodyaznaya, Tatiana Buldakova,
Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Characterization of C-nucleoside Antimicrobials from Streptomyces albus DSM 40763: Strepturidin is Pseudouridimycin (2019)
- Scientific Reports
Rosenqvist P, Palmu K, Prajapati RK, Yamada K, Niemi J, Belogurov GA, Metsa-Ketela M, Virta P
(A1 Refereed original research article in a scientific journal)
Chimeragenesis for Biocatalysis (2019) Advances in Enzyme Technology Pedro Dinis, Benjamin Nji Wandi, Thadée Grocholski, Mikko Metsä-Ketelä
(A3 Refereed book chapter or chapter in a compilation book)
Evolutionary Trajectories for the Functional Diversification of Anthracycline Methyltransferases (2019)
- ACS Chemical Biology
Grocholski T., Yamada K., Sinkkonen J., Tirkkonen H., Niemi J., Metsä-Ketelä M.
(A1 Refereed original research article in a scientific journal)
Oxazinomycin arrests RNA polymerase at the polythymidine sequences (2019)
- Nucleic Acids Research
Prajapati R.K., Rosenqvist P., Palmu K., Mäkinen J.J., Malinen A.M., Virta P., Metsä-Ketelä M., Belogurov G.A.
(A1 Refereed original research article in a scientific journal)
Activation of microbial secondary metabolic pathways: Avenues and challenges (2018)
- Synthetic and Systems Biotechnology
Baral B., Akhgari A., Metsä-Ketelä M.
(A1 Refereed original research article in a scientific journal)
Enzymatic Synthesis of the C-glycosidic Moiety of Nogalamycin R (2018)
- ACS Chemical Biology
Siitonen Vilja, Nji Wandi Benjamin, Törmänen Akke-Pekka, Metsä-Ketelä Mikko
(A1 Refereed original research article in a scientific journal)
Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics (2017)
- ACS Chemical Biology
Kaisa Palmu, Petja Rosenqvist, Keshav Thapa, Yulia Ilina, Vilja Siitonen, Bikash Baral, Janne Mäkinen, Georgi Belogurov, Pasi Virta, Jarmo Niemi, Mikko Metsä-Ketelä
(A1 Refereed original research article in a scientific journal)
Evolution inspired engineering of antibiotic biosynthesis enzymes (2017)
- Organic and Biomolecular Chemistry
M. Metsä-Ketelä
(A2 Refereed review article in a scientific journal )
Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway (2016)
- Proceedings of the National Academy of Sciences of the United States of America
Siitonen V, Selvaraj B, Niiranen L, Lindqvist Y, Schneider G, Metsa-Ketela M
(A1 Refereed original research article in a scientific journal)