Petteri Rinne
PhD
pperin@utu.fi +358 29 450 4632 +358 50 560 9497 Kiinamyllynkatu 10 Turku : C644 |
Cardiovascular diseases; Atherosclerosis; Heart Failure; Cardiovascular Pharmacology; Experimental Research
I work currently as Academy Research Fellow at the University of Turku. I graduated from the Health Biosciences Master's degree programme (University of Turku) with a major in Drug Development. Thereafter, I conducted my PhD studies at the Department of Pharmacology, Drug Development and Therapeutics and graduated in 2013. After doing a short postdoctoral research period at the Turku PET Centre, I was awarded a 3-year postdoctoral fellowship from the Academy of Finland. During this period, I did research at the Institute for Cardiovascular Prevention (IPEK) in Munich, Germany. My current affiliation is Research Center For Integrative Physiology and Pharmacology, Institute of Biomedicine, and my office is located in Medisiina C building.
My current research projects focus on the role of melanocortin and lipid signalling in cardiovascular diseases. In particular, the research aims at evaluating the therapeutic potential of targeting these systems for the management of atherosclerosis. We utilize both loss- and gain-of-function models as
well as pharmacological and genetic approaches to advance our understanding of
the roles of these mediators in atherosclerosis. The projects also combine various in vitro and in vivo models to achieve an extensive view
of the underlying molecular-level mechanisms.
well as pharmacological and genetic approaches to advance our understanding of
the roles of these mediators in atherosclerosis. The projects also combine various in vitro and in vivo models to achieve an extensive view
of the underlying molecular-level mechanisms.
Coronary artery disease arising from atherosclerosis is a common form of cardiovascular disease and an important public
health challenge worldwide. It is lacking effective treatments that would specifically target and reverse the underlying pathology and
disease progression, highlighting the unmet medical need. Our research projects contribute to this need by exploring the possible therapeutic benefits of targeting melanocortin and lipid mediators in atherosclerosis.
health challenge worldwide. It is lacking effective treatments that would specifically target and reverse the underlying pathology and
disease progression, highlighting the unmet medical need. Our research projects contribute to this need by exploring the possible therapeutic benefits of targeting melanocortin and lipid mediators in atherosclerosis.
I am actively involved in teaching activities in courses related to basic and advanced pharmacology, particularly in courses in cardiovascular pharmacology. As I am currently holding a research-oriented position, my contribution to teaching is not very extensive, but besides occasional lecturing, I am mentoring as well as supervising undergraduate and PhD students in their thesis projects.
- Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling (2025)
- Journal of the American Heart Association
- Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy (2024)
- International Journal of Obesity
- The effect of exercise and disease status on mobilization of anti-tumorigenic and pro-tumorigenic immune cells in women with breast cancer (2024)
- Frontiers in Immunology
- α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor (2024)
- EMBO Reports
- Acute exercise mobilizes CD8(+) cytotoxic T cells and NK cells in lymphoma patients (2023)
- Frontiers in Physiology
- Deep Learning-Based Image Analysis of Liver Steatosis in Mouse Models (2023)
- American Journal of Pathology
- Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies (2023)
- Frontiers in Immunology
- Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver (2023)
- eLife
- The effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients (2023)
- Scientific Reports
- GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation (2022)
- Nature cardiovascular research
- Melanocortin 1 Receptor Deficiency in Hematopoietic Cells Promotes the Expansion of Inflammatory Leukocytes in Atherosclerotic Mice (2021)
- Frontiers in Immunology
- Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice (2020)
- European Journal of Pharmacology
- Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice (2020)
- JACC: Basic to Translational Science
- Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner (2019)
- Thrombosis and Haemostasis
- Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Melanocortin overexpression limits diet-induced inflammation and atherosclerosis in LDLR-/- mice (2018)
- Journal of Endocrinology
- Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Pro-opiomelanocortin and its Processing Enzymes Associate with Plaque Stability in Human Atherosclerosis -Tampere Vascular Study (2018)
- Scientific Reports
- Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages (2017)
- Circulation