Petteri Rinne
PhD
pperin@utu.fi +358 29 450 4632 +358 50 560 9497 Kiinamyllynkatu 10 Turku Office: C644 ORCID identifier: https://orcid.org/0000-0001-6916-8627 |
Areas of expertise
Cardiovascular diseases; Atherosclerosis; Heart Failure; Cardiovascular Pharmacology; Experimental Research
Cardiovascular diseases; Atherosclerosis; Heart Failure; Cardiovascular Pharmacology; Experimental Research
Biography
I work currently as Academy Research Fellow at the University of Turku. I graduated from the Health Biosciences Master's degree programme (University of Turku) with a major in Drug Development. Thereafter, I conducted my PhD studies at the Department of Pharmacology, Drug Development and Therapeutics and graduated in 2013. After doing a short postdoctoral research period at the Turku PET Centre, I was awarded a 3-year postdoctoral fellowship from the Academy of Finland. During this period, I did research at the Institute for Cardiovascular Prevention (IPEK) in Munich, Germany. My current affiliation is Research Center For Integrative Physiology and Pharmacology, Institute of Biomedicine, and my office is located in Medisiina C building.
Research
My current research projects focus on the role of melanocortin and lipid signalling in cardiovascular diseases. In particular, the research aims at evaluating the therapeutic potential of targeting these systems for the management of atherosclerosis. We utilize both loss- and gain-of-function models as
well as pharmacological and genetic approaches to advance our understanding of
the roles of these mediators in atherosclerosis. The projects also combine various in vitro and in vivo models to achieve an extensive view
of the underlying molecular-level mechanisms.
well as pharmacological and genetic approaches to advance our understanding of
the roles of these mediators in atherosclerosis. The projects also combine various in vitro and in vivo models to achieve an extensive view
of the underlying molecular-level mechanisms.
Coronary artery disease arising from atherosclerosis is a common form of cardiovascular disease and an important public
health challenge worldwide. It is lacking effective treatments that would specifically target and reverse the underlying pathology and
disease progression, highlighting the unmet medical need. Our research projects contribute to this need by exploring the possible therapeutic benefits of targeting melanocortin and lipid mediators in atherosclerosis.
health challenge worldwide. It is lacking effective treatments that would specifically target and reverse the underlying pathology and
disease progression, highlighting the unmet medical need. Our research projects contribute to this need by exploring the possible therapeutic benefits of targeting melanocortin and lipid mediators in atherosclerosis.
Teaching
I am actively involved in teaching activities in courses related to basic and advanced pharmacology, particularly in courses in cardiovascular pharmacology. As I am currently holding a research-oriented position, my contribution to teaching is not very extensive, but besides occasional lecturing, I am mentoring as well as supervising undergraduate and PhD students in their thesis projects.
Publications
- Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling (2025)
- Journal of the American Heart Association
(A1 Refereed original research article in a scientific journal) - Hepatocyte-specific loss of melanocortin 1 receptor disturbs fatty acid metabolism and promotes adipocyte hypertrophy (2024)
- International Journal of Obesity
(A1 Refereed original research article in a scientific journal) - The effect of exercise and disease status on mobilization of anti-tumorigenic and pro-tumorigenic immune cells in women with breast cancer (2024)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor (2024)
- EMBO Reports
(A1 Refereed original research article in a scientific journal) - Acute exercise mobilizes CD8(+) cytotoxic T cells and NK cells in lymphoma patients (2023)
- Frontiers in Physiology
(A1 Refereed original research article in a scientific journal) - Deep Learning-Based Image Analysis of Liver Steatosis in Mouse Models (2023)
- American Journal of Pathology
(A1 Refereed original research article in a scientific journal) - Editorial: Melanocortins and melanocortin receptors in the regulation of inflammation: mechanisms and novel therapeutic strategies (2023)
- Frontiers in Immunology
(B1 Non-refereed article in a scientific journal) - Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver (2023)
- eLife
(A1 Refereed original research article in a scientific journal) - The effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients (2023)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation (2022)
- Nature cardiovascular research
(A1 Refereed original research article in a scientific journal) - Melanocortin 1 Receptor Deficiency in Hematopoietic Cells Promotes the Expansion of Inflammatory Leukocytes in Atherosclerotic Mice (2021)
- Frontiers in Immunology
(A1 Refereed original research article in a scientific journal) - Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice (2020)
- European Journal of Pharmacology
(A1 Refereed original research article in a scientific journal) - Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice (2020)
- JACC: Basic to Translational Science
(A1 Refereed original research article in a scientific journal) - Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner (2019)
- Thrombosis and Haemostasis
(B1 Non-refereed article in a scientific journal) - Chronic Intake of the Selective Serotonin Reuptake Inhibitor Fluoxetine Enhances Atherosclerosis (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
(A1 Refereed original research article in a scientific journal) - Melanocortin 1 Receptor Deficiency Promotes Atherosclerosis in Apolipoprotein E-/- Mice (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
(A1 Refereed original research article in a scientific journal) - Melanocortin overexpression limits diet-induced inflammation and atherosclerosis in LDLR-/- mice (2018)
- Journal of Endocrinology
(A1 Refereed original research article in a scientific journal) - Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation (2018)
- Arteriosclerosis, Thrombosis, and Vascular Biology
(A1 Refereed original research article in a scientific journal) - Pro-opiomelanocortin and its Processing Enzymes Associate with Plaque Stability in Human Atherosclerosis -Tampere Vascular Study (2018)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages (2017)
- Circulation
(A1 Refereed original research article in a scientific journal)