Hannu Järveläinen
Professor
hanjar@utu.fi +358 29 450 4629 +358 46 922 9617 Kiinamyllynkatu 10 Turku ORCID identifier: https://orcid.org/https://orcid.org/0000-0002-1061-6779 |
extracellular matrix; proteoglycans; decorin; hyaluronan, vascular biology, cancer biology, diabetes, biobank
The extracellular matrix (ECM) consists of numerous macromolecules that
can be classified into collagens, elastin, and microfibrillar proteins,
proteoglycans including hyaluronan, and noncollagenous glycoproteins.
Together they form a complex, three-dimensional network among the cells
of different tissues in an organ-specific manner. In addition to being
necessary structural components, ECM macromolecules exhibit important
functional roles in the control of key cellular events such as adhesion,
migration, proliferation, differentiation, and survival. Any structural
inherited or acquired defect and/or metabolic disturbance in the ECM
macromolecules may cause cellular and tissue alterations that can lead
to the development or progression of disease. Consequently, ECM
macromolecules are important targets for pharmacotherapy. Our interest
has been for a long time to study the role of matrix proteoglycans (PGs)
including hyaluronan in vascular biology. We have particularly focused
on the involvement of a small PG decorin with atherogenesis and
angiogenesis. Lately we have also examined the role of decorin in
tumourigenesis. Our ultimate goal is to develop decorin-based therapies
to prevent luminal narrowing of arteries, to inhibit pathological
angiogenesis and to restrict tumour growth and metastasis.
- Hypoglykemian vaikutus liikenneturvallisuuteen ja ajokykyyn (2019) Diabetes Hannu Järveläinen
(D2 Article in a professional compilation book) - Jalkatyöryhmien merkitys ja toimintaperiaatteet (2019) Diabetes Ebeling Tapani, Järveläinen Hannu, Tapio Anna-Leena, Kaartinen Ilkka, Juutilainen Vesa, Stolt Minna, Huhtanen Jaana
(D2 Article in a professional compilation book) - Lääkärin ilmoitusvelvollisuus ajokorttilupaan ja ajo-oikeuteen liittyen (2019) Diabetes Hannu Järveläinen
(D2 Article in a professional compilation book) - Simvastatin Modulates Extracellular Matrix Assembly by Displaying an Antifibrotic Activity in Vitro (2019)
- Journal of Pharmacy and Pharmacology Research
(A1 Refereed original research article in a scientific journal) - Targeting Hyaluronan in Vascular Diseases with Special Reference to Diabetic Macroangiopathy (2019)
- Biomedical Journal of Scientific & Technical Research
(A2 Refereed review article in a scientific journal ) - A novel double nucleotide variant in the ferritin-L iron-responsive element in a Finnish patient with hereditary hyperferritinaemia-cataract syndrome (2018)
- Acta Ophthalmologica
(A1 Refereed original research article in a scientific journal) - Extracellular Matrix Macromolecules as Potential Targets of Cardiovascular Pharmacotherapy (2018) Vascular Pharmacology: Cytoskeleton and Extracellular Matrix Sainio A, Järveläinen H
(B2 Non-refereed book chapter or chapter in a compilation book) - Uusi täsmälääkeryhmä näköpiirissä tyypin 2 diabetekseen (2018)
- Lääkärilehti
(D1 Article in a professional journal) - Alaraajojen verenkierron tutkiminen (2017) Jalkaterveys Hannu Järveläinen
(D2 Article in a professional compilation book) - Diabeetikon jalkaongelmat: syntyy vaikuttavat tekijät, yleisyys ja kustannukset (2017) Jalkaterveys Hannu Järveläinen
(D2 Article in a professional compilation book) - Diabeetikon jalkojenhoidon seuranta ja omahoidon ohjaus (2017) Jalkaterveys Anna-Leena Tapio, Hannu Järveläinen,
(D2 Article in a professional compilation book) - Human Metaplastic Breast Carcinoma and Decorin (2017)
- Cancer Microenvironment
(A1 Refereed original research article in a scientific journal) - Kansallisaarre - kokemuksia Auria-biopankista (2017)
- Diabetes ja lääkäri
(D1 Article in a professional journal) - Suurentunut ferritiinipitoisuus - hämärtääkö näköä? (2017)
- Duodecim
(D1 Article in a professional journal) - Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells (2016)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Onko DPP-4:n estäjien suosio diabeteksen hoidossa perusteltua? (2016)
- Lääkärilehti
(D1 Article in a professional journal) - Uusi glukoosin omaseurantalaite – käytännön kokemuksia (2016)
- Lääkärilehti
(D1 Article in a professional journal) - Decorin in Human Colon Cancer: Localization In Vivo and Effect on Cancer Cell Behavior In Vitro. (2015)
- Journal of Histochemistry and Cytochemistry
(A1 Refereed original research article in a scientific journal) - Pivotal role for decorin in angiogenesis (2015)
- Matrix Biology
(A2 Refereed review article in a scientific journal ) - Extracellular matrix macromolecules: potential tools and targets in cancer gene therapy. (2014)
- Molecular and Cellular Therapies
(A2 Refereed review article in a scientific journal )