Jarmo Niemi
Ph.D.
jarnie@utu.fi +358 29 450 4701 +358 50 470 4758 Tykistökatu 6 Turku Office: B6130 ORCID identifier: https://orcid.org/0000-0002-7447-8379 |
Antibiotic biosynthesis; biology of Streptomyces; protein research
I started work with antibiotic biosynthesis in 1985, when I worked
for the Finnish pharmaceutical company Leiras, and have continued it
since, except for 1995-1998, when I worked in a project concerning
high-throughput screening methods for peptide receptor agonists.
My Ph. D. thesis in 1995 was about "Hybrid
Anthracycline Antibiotics: Analysis and
Application
of Rhodomycin Biosynthetic Genes from Streptomyces purpurascens".
My
research has concerned the biosynthesis of antibiotics by Streptomyces,
its molecular biology, enzymology and structural biology. I continue to
participate in the research of the "Antibiotic biosynthesis
engineering" group http://abelab.utu.fi/
I teach several initial level Biochemistry courses at the University of Turku; BKEM5030 Cell and Biomolecules - Theory, BKEM5010 Microbiology - Theory, BKEM5011 Microbiology - Practice and part of BKEM5160 Cell and Energy - Theory and BKEM5161 Cell and Energy - Practice.
I also teach the course BJ01A1060 Basic Biochemistry at the Lappeenranta University of Technology.
- Crystallization and preliminary X-ray diffraction studies of aclacinomycin-10-methyl esterase and aclacinomycin-10-hydroxylase from Streptomyces purpurascens (2003)
- Acta Crystallographica Section D: Biological Crystallography
(A1 Refereed original research article in a scientific journal) - Crystal structure of aclacinomycin-10-hydroxylase, a S-adenosyl-L-methionine-dependent methyltransferase homolog involved in anthracycline biosynthesis in Streptomyces purpurascens (2003) Jansson A, Niemi J, Lindqvist Y, Mantsala P, Schneider G
(A1 Refereed original research article in a scientific journal) - Crystal structure of aclacinomycin methylesterase with bound product analogues - Implications for anthracycline recognition and mechanism (2003)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Anthracycline biosynthesis: Steps, enzymes and genes (2002) Microbial Secondary Metabolites: Biosynthesis, Genetics and Regulation Niemi Jarmo, Kantola Jaana, Ylihonko Kristiina, Mäntsälä Pekka
(B2 Non-refereed book chapter or chapter in a compilation book) - Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products (2002)
- FEMS Microbiology Letters
(A1 Refereed original research article in a scientific journal) - Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens (2000)
- Biochimica et Biophysica Acta: Protein Structure and Molecular Enzymology
(A1 Refereed original research article in a scientific journal) - Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens (1999)
- Biochimica et Biophysica Acta: Protein Structure and Molecular Enzymology
(A1 Refereed original research article in a scientific journal) - Hybrid anthracyclines by a genetically engineered Streptomyces galilaeus mutant (1997)
- Bioorganic and Medicinal Chemistry Letters
(A1 Refereed original research article in a scientific journal) - NUCLEOTIDE-SEQUENCES AND EXPRESSION OF GENES FROM STREPTOMYCES-PURPURASCENS THAT CAUSE THE PRODUCTION OF NEW ANTHRACYCLINES IN STREPTOMYCES-GALILAEUS (1995)
- Journal of Bacteriology
(A1 Refereed original research article in a scientific journal) - HYBRID ANTHRACYCLINE ANTIBIOTICS - PRODUCTION OF NEW ANTHRACYCLINES BY CLONED GENES FROM STREPTOMYCES-PURPURASCENS IN STREPTOMYCES-GALILAEUS (1994)
- Microbiology
(A1 Refereed original research article in a scientific journal) - ISOLATION AND CHARACTERIZATION OF ACLACINOMYCIN-A-NON-PRODUCING STREPTOMYCES-GALILAEUS (ATCC-31615) MUTANTS (1994)
- Microbiology
(A1 Refereed original research article in a scientific journal) - TRACTOR, a program to locate subclones in a nucleotide sequence using only one sequencing reaction (1994)
- Computer Applications in the Biosciences
Mäntsälä P
(A1 Refereed original research article in a scientific journal) - ABAA, A NEW PLEIOTROPIC REGULATORY LOCUS FOR ANTIBIOTIC PRODUCTION IN STREPTOMYCES-COELICOLOR (1992)
- Journal of Bacteriology
(A1 Refereed original research article in a scientific journal) - CLONING AND EXPRESSION IN A HETEROLOGOUS HOST OF THE COMPLETE SET OF GENES FOR BIOSYNTHESIS OF THE STREPTOMYCES-COELICOLOR ANTIBIOTIC UNDECYLPRODIGIOSIN (1990)
- Gene
(A1 Refereed original research article in a scientific journal) - EXPRESSION OF HETEROLOGOUS GENE AND SECRETION OF ITS PRODUCT IN ESCHERICHIA-COLI (1987)
- Protein Engineering
(A1 Refereed original research article in a scientific journal) - A NEW APPROACH TO HIGH-SENSITIVITY DIFFERENTIAL HYBRIDIZATION (1986)
- Gene
(A1 Refereed original research article in a scientific journal)



