Antti-Pekka Laine

- Senior Researcher,
Institute of Biomedicine (Faculty of Medicine)
- Project Researcher,
MediCity (Faculty of Medicine)

aplaine@utu.fi

+358 29 450 4386

+358 50 352 0067

Tykistökatu 6

Turku

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Transmission disequilibrium analysis of 31 type 1 diabetes susceptibility loci in Finnish families (2013)
- Tissue Antigens
Laine AP, Knip M, Ilonen J, The Finnish Pediatric Diabetes Register
Novel Function for Small GTPase Coding GIMAP Family Genes in Human T Helper Cell Differentiation and Autoimmunity (2011)
- Scandinavian Journal of Immunology
Heinonen M, Laine AP, Knip M, Ilonen J, Lahesmaa R, Henttinen T
Progression of type 1 diabetes associated autoimmunity and the high-risk HLA class II genotype (2011)
- Diabetologia
Ilonen J, Lempainen J, Hammais A, Laine AP, Hermann R, Veijola R, Simell O, Harkonen T, Knip M
The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations (2010)
- Diabetologia
Jermendy A, Szatmari I, Laine AP, Lukacs K, Horvath KH, Korner A, Madacsy L, Veijola R, Simell O, Knip M, Ilonen J, Hermann R
Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates (2009)
- Human Immunology
Douroudis K, Laine AP, Heinonen M, Hermann R, Lipponen K, Veijola R, Simell O, Knip M, Uibo R, Ilonen J, Kisand K
Method for high-throughput screening of HLA-B*39 allele to be used in the assessment of genetic risk for type 1 diabetes (2008)
- Diabetologia
Kiviniemi M, Laine AP, Gombos Z, Hermann R, Knip M, Nurmi J, Lovgren T, Ilonen J
The 3q21-region is showing moderate evidence for association with type 1 diabetes in three Finnish family datasets (2008)
- Diabetologia
Laine AP, Veijola R, Simell O, Knip M, Ilonen J
Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations (2007)
- Disease Markers
Laine AP, Holmberg H, Nilsson A, Ortqvist E, Kiviniemi M, Vaarala O, Akerblom HK, Simell O, Knip M, Ludvigsson J, Ivarsson SA, Larsson K, Lernmark A, Ilonen J
Association of tumour necrosis factor a, b and c microsatellite polymorphisms with clinical disease activity and induction of remission in early rheumatoid arthritis (2006)
- Clinical and Experimental Rheumatology
Laivoranta-Nyman S, Mottonen T, Hannonen P, Korpela M, Kautlainen H, Leirisalo-Repo M, Julkunen H, Luukkainen R, Hakala M, Vuori K, Laine AP, Toivanen A, Ilonen J
Evidence for linkage to and association with type 1 diabetes at the 3q21 region in the Finnish population (2006)
- Genes and Immunity
Laine AP, Turpeinen H, Veijola R, Hermann R, Simell O, Knip M, Ilonen J
The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity (2005)
- Diabetologia
Hermann R, Laine AP, Veijola R, Vahlberg T, Simell S, Lahde J, Simell O, Knip M, Ilonen J
Y-chromosome phylogenetic analysis to dissect type 1 diabetes genetic heterogeneity (2005)
- Diabetologia
Hermann R, Kiss K, Laine AP, Veijola R, Huoponen K, Akerblom HK, Simell O, Knip M, Ilonen J
A linkage study of 12 IDDM susceptibility loci in the Finnish population (2004) Laine AP, Nejentsev S, Veijola R, Korpinen E, Sjoroos M, Simell O, Knip M, Akerblom HK, Ilonen J
Mitochondrial DNA phylogenic lineages for mapping Type 1 diabetes genes (2004)
- Diabetologia
Hermann R, Kakko T, Laine AP, Veijola R, Huoponen K, Savontaus ML, Knip M, Ilonen J, Hermann R, Kakko T, Laine AP, Veijola R, Huoponen K, Savontaus ML, Knip M, Ilonen J
The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population (2004)
- Tissue Antigens
Laine AP, Hermann R, Knip M, Simell O, Akerblom HK, Ilonen J
Type 1 diabetes is insulin-2221 MspI and CTLA-4+49 A/G polymorphism dependent (2004)
- European Journal of Clinical Investigation
Haller K, Kisand K, Nemvalts V, Laine AP, Ilonen J, Uibo R
Type 1 diabetes is insulin MSPI-2221 and CTLA-4+49 A/G polymorphism dependent. The logistic regression analyses (2004)
- Tissue Antigens
Haller K, Kisand K, Nemvalts V, Laine AP, Ilonen J, Uibo R
A linkage analysis of the CTLA4 gene region in Finnish patients with type 1 diabetes (2003)
- European Journal of Immunogenetics
Turpeinen H, Laine AP, Hermann R, Simell O, Veijola R, Knip M, Ilonen J
HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: An analysis of 622 nuclear families (2003)
- Tissue Antigens
Hermann R, Turpeinen H, Laine AP, Veijola R, Knip M, Simell O, Sipila I, Akerblom HK, Ilonen J
Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes - indication of an increased environmental pressure? (2003)
- Diabetologia
Hermann R, Knip M, Veijola R, Simell O, Laine AP, Akerblom HK, Groop PH, Forsblom C, Pettersson-Fernholm K, Ilonen J