Antti-Pekka Laine

- Senior Researcher,
Institute of Biomedicine (Faculty of Medicine)
- Project Researcher,
MediCity (Faculty of Medicine)

aplaine@utu.fi

+358 29 450 4386

+358 50 352 0067

Tykistökatu 6

Turku

1 of 3

CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparityNon-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects (2023)
- Frontiers in GeneticsJournal of Infectious Diseases
Nygård Lucas, Valta Milla, Laine Antti-Pekka, Toppari Jorma, Knip Mikael, Veijola Riitta, Hyöty Heikki, Ilonen Jorma, Lempainen Johanna
Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes (2022)
- Pediatric Diabetes
Ilonen Jorma, Laine Antti-Pekka, Kiviniemi Minna, Härkonen Taina, Lempainen Johanna, Knip Mikael
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage (2022)
- Diabetologia
Sioofy-Khojine Amir-Babak, Richardson Sarah J., Locke Jonathan M., Oikarinen Sami, Nurminen Noora, Laine Antti-Pekka, Downes Kate, Lempainen Johanna, Todd John A., Veijola Riitta, Ilonen Jorma, Knip Mikael, Morgan Noel G., Hyöty Heikki, Peakman Mark, Eichmann Martin
2022
- Frontiers in ImmunologyDiabetes
Laine Antti-Pekka, Valta Milla, Toppari Jorma, Knip Mikael, Veijola Riitta, Ilonen Jorma, Lempainen Johanna
(2021)
Lempainen Johanna, Korhonen Laura S, Kantojärvi Katri, Heinonen Santtu, Toivonen Laura, Räty Panu, Ramilo Octavio, Mejias Asuncion, Laine Antti-Pekka, Vuorinen Tytti, Waris Matti, Karlsson Linnea, Karlsson Hasse, Paunio Tiina, Peltola Ville
Tri-SNP polymorphism in the intron of HLA-DRA1 affects type 1 diabetes susceptibility in the Finnish population (2021)
- Human Immunology
Nygård Lucas, Laine Antti-Pekka, Kiviniemi Minna, Toppari Jorma, Härkönen Taina, Knip Mikael, Veijola Rittta, Lempainen Johanna, Ilonen Jorma
HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity (2020)
- Pediatric Diabetes
Mikk Mari-Liis, Pfeiffer Sophie, Kiviniemi Minna, Laine Antti-Pekka, Lempainen Johanna, Härkönen Taina, Toppari Jorma, Veijola Riitta, Knip Mikael, Ilonen Jorma; The Finnish Pediatric Diabetes Register
Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies (2020)
Maarit K. Koskinen, Mari-Liis Mikk, Antti-Pekka Laine, Johanna Lempainen, Eliisa Löyttyniemi, Paula Vähäsalo, Anne Hekkala, Taina Härkönen, Minna Kiviniemi, Olli Simell, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari
Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk (2019)
- Journal of Clinical Endocrinology and Metabolism
Siljander H., Ilonen J., Knip M., Pöllänen P., Lempainen J., Laine A., Toppari J., Veijola R.
Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity (2018)
- Pediatric Diabetes
Jorma Ilonen, Johanna Lempainen, Anna Hammais, Antti-Pekka Laine, Taina Härkönen, Jorma Toppari, Riitta Veijola, Mikael Knip
Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility (2017)
- Diabetologia
Pollanen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Vahasalo P, Ilonen J, Siljander H, Knip M
HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes (2017)
- PLoS ONE
Parkkola A, Laine AP, Karhunen M, Härkönen T, Ryhänen SJ, Ilonen J, Knip M
The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns (2017)
- HLA
Mikk ML, Heikkinen T, El-Amir MI, Kiviniemi M, Laine AP, Harkonen T, Veijola R, Toppari J, Knip M, Ilonen J
GIMAP GTPase Family Genes: Potential Modifiers in Autoimmune Diabetes, Asthma, and Allergy (2015)
- Journal of Immunology
Heinonen MT, Laine AP, Soderhall C, Gruzieva O, Rautio S, Melen E, Pershagen G, Lahdesmaki HJ, Knip M, Ilonen J, Henttinen TA, Kere J, Lahesmaa R
Non-HLA gene effects on the disease process of type 1 diabetes: From HLA susceptibility to overt disease (2015)
- Journal of Autoimmunity
Lempainen J, Laine AP, Hammais A, Toppari J, Simell O, Veijola R, Knip M, Ilonen J
Risk genes and autoantibodies in Egyptian children with type 1 diabetes - low frequency of autoantibodies in carriers of the HLA-DRB1*04:05-DQA1*03-DQB1*02 risk haplotype (2015)
- Diabetes/Metabolism Research and Reviews
Mostafa I. El-Amir, Mohamed Ali El-Feky, Antti-Pekka Laine, Taina Härkönen, Omnia El-Badawy, Azza A. Eltayeb, Tarek Taha El-Melegy, Minna Kiviniemi, Mikael Knip, Jorma Ilonen
Circulating concentrations of soluble receptor for AGE are associated with age and AGER gene polymorphisms in children with newly diagnosed type 1 diabetes (2014)
- Diabetes Care
Kirsi M. Salonen, Samppa J. Ryhänen, Josephine M. Forbes, Taina Härkönen, Jorma Ilonen, Antti-Pekka Laine, Per-Henrik Groop, Mikael Knip for the Finnish Pediatric Diabetes Registe
The HLA-B∗39 allele increases type 1 diabetes risk conferred by HLA-DRB1∗04:04-DQB1∗03:02 and HLA-DRB1∗08-DQB1∗04 class II haplotypes (2014)
- Human Immunology
M.-L. Mikk, M. Kiviniemi, A.-P. Laine, T. Härkönen, R. Veijola, O. Simell, M. Knip, J. Ilonen; and the Finnish Paediatric Diabetes Register
Associations of polymorphisms in non-HLA loci with autoantibodies at the diagnosis of type 1 diabetes – INS and IKZF4 associate with insulin autoantibodies (2013)
- Pediatric Diabetes
Lempainen J, Härkönen T, Laine AP, Knip M, Ilonen J, The Finnish Pediatric Diabetes Register
Patterns of beta-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life (2013)
- Diabetes
Ilonen J, Hammais A, Laine AP, Lempainen J, Vaarala O, Veijola R, Simell O, Knip M