Kaisa Ivaska-Papaioannou
PhD, Adjunct professor (docent)
kaisa.ivaska@utu.fi +358 29 450 4622 +358 50 407 6533 Kiinamyllynkatu 10 Turku Office: C440 ORCID identifier: https://orcid.org/0000-0001-7482-7623 |
bone; bone cell biology; bone metabolism; bone turnover markers; bone marrow adiposity; osteoporosis; diabetes; biomedicine; cell biology
Bone and Energy Metabolism, BoneLab Turku
Senior Lecturer in Cell Biology and Metabolism
Docent in Cell Biology 2012
Bone and energy metabolism
Our reserach group is interested in the crosstalk between bone cells and energy metabolism.
Bone is not only a structural organ but interacts with other cell types in the bone marrow microenvironment and interestingly, also with extra-skeletal cells via bone-derived hormones, osteokines.
Our current research focuses on role of osteokines in local and whole body energy metabolism, and in the interactions between bone-forming osteoblasts and bone marrow adipocytes in the bone microenvironment. We are also interested in the effects of type 2 diabetes on bone cells and bone metabolism. We use cell culture and cell-based methods, in vivo models and patient samples obtained from our clinical collaborators.
Our long term goal is to understand how changes in energy metabolism affect bone cells, bone marrow adipocytes and osteokines in the bone microenvironment.
Group members: Niki Jalava (doctoral researcher), Nicko Widjaja (doctoral researcher), Trine Link (undergraduate student)
Funding: Academy of Finland (2019-24), Laboratoriolääketieteen edistämissäätiö, Turku University Foundation, Diabetes Wellness Finland, Finnish Cultural Foundation
Alumni: Mlja Arponen (PhD 2024), Ronja Ojala (MD PhD 2024), Iida Karhu (MSc 2024), Aapo Alhokankare (MSc 2023), Yimeng Chen (MSc 2022), Sana Rais (MSc 2022), Nicko Widjaja (MSc 2021), Tiina Kähkönen (PhD 2019), Milja Arponen (MSc 2016), Anna-Reetta Virta (MSc 2014)
Cell biology and histology for students in Medicine (first year) and Biomedicine (Bachelor’s Degree Programme). Textbooks Alberts et al. Essential Cell Biology, Young et al. Wheater's Functional Histology.
Laboratory course "Cell and Molecular Biology (laboratory work)" for students in Biomedicine
Laboratory course "Methods in Cell Biology" and for medical students selected for Molecular Medicine Research Track (2-yr programme)
Participating actively in the planning of the curriculum (in particular, first year BSc studies).
- Bone turnover markers are correlated with quantitative ultrasound of the calcaneus: 5-year longitudinal data (2009)
- Osteoporosis International
(A1 Refereed original research article in a scientific journal) - Bone turnover markers are correlated with total skeletal uptake of 99mTc-methylene diphosphonate (99mTc-MDP). (2009)
- BMC Medical Physics
(A1 Refereed original research article in a scientific journal) - Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro (2009)
- BONE
(A1 Refereed original research article in a scientific journal) - Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk (2008)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Urinary osteocalcin and other markers of bone metabolism: the effect of risedronate therapy (2008)
- Scandinavian Journal of Clinical and Laboratory Investigation
(A1 Refereed original research article in a scientific journal) - Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women (2007)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - Effect of fracture on bone turnover markers: A longitudinal study comparing marker levels before and after injury in 113 elderly women (2007)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - Prediction of bone loss using biochemical markers of bone turnover (2007)
- Osteoporosis International
(A1 Refereed original research article in a scientific journal) - Calcification and cellularity in human aortic heart valve tissue determine the differentiation of bone-marrow-derived cells (2006)
- Journal of Molecular and Cellular Cardiology
(A1 Refereed original research article in a scientific journal) - Biochemical markers of bone turnover are influenced by recently sustained fracture (2005)
- BONE
(A1 Refereed original research article in a scientific journal) - Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial (2005)
- American Journal of Clinical Nutrition
(A1 Refereed original research article in a scientific journal) - Serum TRACP 5b is a useful marker for monitoring alendronate treatment: Comparison with other markers of bone turnover (2005)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - Urinary osteocalcin as a marker of bone metabolism (2005)
- Clinical Chemistry
(A1 Refereed original research article in a scientific journal) - Urinary osteocalcin is a useful marker for monitoring the effect of alendronate therapy (2005)
- Clinical Chemistry
(A1 Refereed original research article in a scientific journal) - Biochemical markers of bone metabolism and prediction of fracture in elderly women (2004)
- Journal of Bone and Mineral Research
(A1 Refereed original research article in a scientific journal) - Development of sensitive immunoassays for free and total human glandular kallikrein 2 (2004)
- Clinical Chemistry
(A1 Refereed original research article in a scientific journal) - Osteoclast-derived serum tartrate-resistant acid phosphatase 5b in Albers-Schonberg disease (Type II autosomal dominant osteopetrosis) (2004)
- Clinical Chemistry
(A1 Refereed original research article in a scientific journal) - Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro (2004)
- Journal of Biological Chemistry
(A1 Refereed original research article in a scientific journal) - Serum estradiol, testosterone, and sex hormone-binding globulin as regulators of peak bone mass and bone turnover rate in young Finnish men (2004)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Identification of novel proteolytic forms of osteocalcin in human urine (2003)
- Biochemical and Biophysical Research Communications
(A1 Refereed original research article in a scientific journal)
