Kaisa Ivaska-Papaioannou
PhD, Adjunct professor (docent)
kaisa.ivaska@utu.fi +358 29 450 4622 +358 50 407 6533 Kiinamyllynkatu 10 Turku Office: C440 ORCID identifier: https://orcid.org/0000-0001-7482-7623 |
bone; bone cell biology; bone metabolism; bone turnover markers; bone marrow adiposity; osteoporosis; diabetes; biomedicine; cell biology
Bone and Energy Metabolism, BoneLab Turku
Senior Lecturer in Cell Biology and Metabolism
Docent in Cell Biology 2012
Bone and energy metabolism
Our reserach group is interested in the crosstalk between bone cells and energy metabolism.
Bone is not only a structural organ but interacts with other cell types in the bone marrow microenvironment and interestingly, also with extra-skeletal cells via bone-derived hormones, osteokines.
Our current research focuses on role of osteokines in local and whole body energy metabolism, and in the interactions between bone-forming osteoblasts and bone marrow adipocytes in the bone microenvironment. We are also interested in the effects of type 2 diabetes on bone cells and bone metabolism. We use cell culture and cell-based methods, in vivo models and patient samples obtained from our clinical collaborators.
Our long term goal is to understand how changes in energy metabolism affect bone cells, bone marrow adipocytes and osteokines in the bone microenvironment.
Group members: Niki Jalava (doctoral researcher), Nicko Widjaja (doctoral researcher), Trine Link (undergraduate student)
Funding: Academy of Finland (2019-24), Laboratoriolääketieteen edistämissäätiö, Turku University Foundation, Diabetes Wellness Finland, Finnish Cultural Foundation
Alumni: Mlja Arponen (PhD 2024), Ronja Ojala (MD PhD 2024), Iida Karhu (MSc 2024), Aapo Alhokankare (MSc 2023), Yimeng Chen (MSc 2022), Sana Rais (MSc 2022), Nicko Widjaja (MSc 2021), Tiina Kähkönen (PhD 2019), Milja Arponen (MSc 2016), Anna-Reetta Virta (MSc 2014)
Cell biology and histology for students in Medicine (first year) and Biomedicine (Bachelor’s Degree Programme). Textbooks Alberts et al. Essential Cell Biology, Young et al. Wheater's Functional Histology.
Laboratory course "Cell and Molecular Biology (laboratory work)" for students in Biomedicine
Laboratory course "Methods in Cell Biology" and for medical students selected for Molecular Medicine Research Track (2-yr programme)
Participating actively in the planning of the curriculum (in particular, first year BSc studies).
- Altered skull and bone morphology in hyperthyroid knock-in mice with TSHR M453T and D633H mutations (2024)
- Endocrine Abstracts
(Other publication) - Bone marrow metabolism is affected by body weight and response to exercise training varies according to anatomical location (2024)
- Diabetes, Obesity and Metabolism
(A1 Refereed original research article in a scientific journal) - Evaluation of bone marrow glucose uptake and adiposity in male rats after diet and exercise interventions (2024)
- Frontiers in Endocrinology
(A1 Refereed original research article in a scientific journal) - Short- and long-term exposure to high glucose induces unique transcriptional changes in osteoblasts in vitro (2024)
- Biology Open
(A1 Refereed original research article in a scientific journal) - The complex role of Rcor2 : Regulates mesenchymal stromal cell differentiation in vitro but is dispensable in vivo (2024)
- BONE
(A1 Refereed original research article in a scientific journal) - Perilipin-1 immunostaining improves semi-automated digital quantitation of bone marrow adipocytes in histological bone sections (2023)
- Adipocyte
(A1 Refereed original research article in a scientific journal) - The evolution of the adolescent growth spurt: Urinary biomarkers of bone turnover in wild chimpanzees (Pan troglodytes) (2023)
- Journal of Human Evolution
(A1 Refereed original research article in a scientific journal) - Age-Progressive and Gender-Dependent Bone Phenotype in Mice Lacking Both Ebf1 and Ebf2 in Prrx1-Expressing Mesenchymal Cells (2022)
- Calcified Tissue International
(A1 Refereed original research article in a scientific journal) - Ben som endokrint organ: skelettets samverkan med övriga vävnader kan ge benmarkörer nya innebörder (2022)
- Klinisk Biokemi i Norden
(D1 Article in a professional journal) - Bone Turnover Marker Profiling and Fracture Risk in Older Women: Fracture Risk from Age 75 to 90 (2022)
- Calcified Tissue International
(A1 Refereed original research article in a scientific journal) - Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism (2022)
- Frontiers in Physiology
(A1 Refereed original research article in a scientific journal) - Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society (2021)
- Frontiers in Endocrinology
(A2 Refereed review article in a scientific journal ) - Luu endokriinisenä elimenä: luuston vuorovaikutukset muiden kudosten kanssa voivat antaa uusia merkityksiä luumerkkiaineille (2021)
- Kliin lab
(D1 Article in a professional journal) - Serum and Urinary Osteocalcin in Healthy 7- to 19-Year-Old Finnish Children and Adolescents (2021)
- Frontiers in Pediatrics
(A1 Refereed original research article in a scientific journal) - Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training (2020)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Effects of FGFR inhibitors TKI258, BGJ398 and AZD4547 on breast cancer cells in 2D, 3D and tissue explant cultures (2020)
- Cellular Oncology
(A1 Refereed original research article in a scientific journal) - Human Bone Marrow Adipose Tissue is a Metabolically Active and Insulin-Sensitive Distinct Fat Depot (2020)
- Journal of Clinical Endocrinology and Metabolism
(A1 Refereed original research article in a scientific journal) - Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation (2020)
- Calcified Tissue International
(A1 Refereed original research article in a scientific journal) - Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model (2019)
- Journal of Bone Oncology
(A1 Refereed original research article in a scientific journal) - Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. A complex association with bone? (2018)
- PLoS ONE
(A1 Refereed original research article in a scientific journal)
