A2 Refereed review article in a scientific journal
Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS)
Authors: Tencerova, M; Palmisano, B; Lucas, S; Attané, C; Ivaska, KK, Loisay, L; Ikushima, YM; Trivanovic, D; Corsi, A; Roque, A; Li, H; Behler-Janbeck, F; Geurts, J; Riminucci, M; Podgorski, I; Cawthorn, WP; van der Eerden, BCJ; van Wijnen, AJ
Publication year: 2025
Journal: Bone Reports
Journal name in source: Bone reports
Journal acronym: Bone Rep
Volume: 26
eISSN: 2352-1872
DOI: https://doi.org/10.1016/j.bonr.2025.101861
Web address : https://doi.org/10.1016/j.bonr.2025.101861
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/499437765
Bone marrow adipose tissue (BMAT) is physiologically linked to bone and energy metabolism, endocrine regulation, hematopoiesis and cancer-related processes. A key challenge in the field is that methods for isolating BMAT or bone marrow adipocytes (BMAds) are variable because there are no widely adopted standardized protocols. To generate awareness of this challenge and to establish uniformity in experimental approaches requiring isolation, storage and characterization of BMAT and BMAds, the Biobanking Working Group of the international Bone Marrow Adiposity Society (BMAS) has previously recommended experimental standards. This paper provides an update on this effort and presents current state-of-the-art methods and technical considerations for isolation and characterization of BMAT and BMAds, including currently available high-throughput omics approaches. This review provides a reference point based on the consensus view of BMAS investigators to support studies on biomedical, biological, biochemical and biophysical questions associated with bone marrow adiposity.
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Funding information in the publication:
US based investigators that participated in the study were supported in part by funding from the National Institutes of Health through the following awards: R01-AR076357 and R01-AR083398 (HL), R01-CA251394 (IP) and R01–049069 (AJvW).
