Kaisa Ivaska-Papaioannou
PhD, Associate professor (docent)
kaisa.ivaska@utu.fi +358 29 450 4622 +358 50 407 6533 Kiinamyllynkatu 10 Turku Office: C421 ORCID identifier: https://orcid.org/0000-0001-7482-7623 |
bone; bone cell biology; bone metabolism; bone turnover markers; bone marrow adiposity; osteoporosis; diabetes; biomedicine; cell biology
Senior Lecturer in Cell Biology and Metabolism
Docent in Cell Biology 2012
Bone and energy metabolism
Bone is not only a structural organ but interacts with other cells in the bone marrow microenvironment and exerts endocrine functions. Our reserach group is interested in the crosstalk between bone metabolism and energy metabolism.
Our current research topics include the role of bone-derived hormones, or osteokines, in local and whole body energy metabolism, and the interactions between bone cells and bone marrow adipocytes in bone microenvironment. We are also interested in the effects of type 2 diabetes on bone metabolism and bone metabolic markers.. Our long term goal is to understand how changes in energy metabolism affect bone cells, bone-derived hormones, bone turnover and bone microenvironment. We use cell culture and cell-based methods, in vivo models and patient samples obtained from our clinical collaborators.
Group members: Milja Arponen (PhD student), Niki Jalava (PhD student), Nicko Widjaja (PhD student), Ronja Ojala (PhD student, Turku PET Centre)
Funding: Academy of Finland
- Cell biology and histology for students in Medicine (first year) and Biomedicine (Bachelor’s Degree Programme).
- Textbooks we use: Alberts et al. Essential Cell Biology, Alberts et al. Molecular BIology of the Cell, Young et al. Wheater's Functional Histology.
- Laboratory course "Cell and Molecular Biology (laboratory work)" for students in Biomedicine
- Laboratory course "Methods in Cell Biology" and for medical students selected for Molecular Medicine Research Track (2-yr programme).
- Mentoring students in biomedicine (3-yr Bachelor’s Degree Programme).
- Participating actively in the planning of the curriculum (in particular, first year BSc studies).
- Age-Progressive and Gender-Dependent Bone Phenotype in Mice Lacking Both Ebf1 and Ebf2 in Prrx1-Expressing Mesenchymal Cells (2022)
- Calcified Tissue International
(Refereed journal article or data article (A1)) - Ben som endokrint organ: skelettets samverkan med övriga vävnader kan ge benmarkörer nya innebörder (2022)
- Klinisk Biokemi i Norden
(Article in trade journal or blog post (D1)) - Bone Turnover Marker Profiling and Fracture Risk in Older Women: Fracture Risk from Age 75 to 90. (2022)
- Calcified Tissue International
(Refereed journal article or data article (A1)) - Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism (2022)
- Frontiers in Physiology
(Refereed journal article or data article (A1)) - Guidelines for Biobanking of Bone Marrow Adipose Tissue and Related Cell Types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society (2021)
- Frontiers in Endocrinology
(Refereed review article in scientific journal (A2)) - Luu endokriinisenä elimenä: luuston vuorovaikutukset muiden kudosten kanssa voivat antaa uusia merkityksiä luumerkkiaineille (2021)
- Kliin lab
(Article in trade journal or blog post (D1)) - Serum and Urinary Osteocalcin in Healthy 7- to 19-Year-Old Finnish Children and Adolescents (2021)
- Frontiers in Pediatrics
(Refereed journal article or data article (A1)) - Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training (2020)
- Journal of Clinical Endocrinology and Metabolism
(Refereed journal article or data article (A1)) - Effects of FGFR inhibitors TKI258, BGJ398 and AZD4547 on breast cancer cells in 2D, 3D and tissue explant cultures (2020)
- Cellular Oncology
(Refereed journal article or data article (A1)) - Human Bone Marrow Adipose Tissue is a Metabolically Active and Insulin-Sensitive Distinct Fat Depot (2020)
- Journal of Clinical Endocrinology and Metabolism
(Refereed journal article or data article (A1)) - Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation (2020)
- Calcified Tissue International
(Refereed journal article or data article (A1)) - Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model (2019)
- Journal of Bone Oncology
(Refereed journal article or data article (A1)) - Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. A complex association with bone? (2018)
- PLoS ONE
(Refereed journal article or data article (A1)) - Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes (2018)
- Molecular and Cellular Endocrinology
(Refereed journal article or data article (A1)) - Testicular Function and Bone in Young Men with Severe Childhood-Onset Obesity (2018)
- Hormone Research in Paediatrics
(Refereed journal article or data article (A1)) - Changes in bone metabolism after bariatric surgery by gastric bypass or sleeve gastrectomy (2017)
- BONE
(Refereed journal article or data article (A1)) - Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength (2016)
- European Journal of Endocrinology
(Refereed journal article or data article (A1)) - Obese young adults exhibit lower total and lower free serum 25-hydroxycholecalciferol in a randomized vitamin D intervention (2016)
- Clinical Endocrinology
(Refereed journal article or data article (A1)) - Increased Body Adiposity and Serum Leptin Concentrations in Very Long-Term Adult Male Survivors of Childhood Acute Lymphoblastic Leukemia (2015)
- Hormone Research in Paediatrics
(Refereed journal article or data article (A1)) - The effects of acute hyperinsulinemia on bone metabolism (2015)
- Endocrine Connections
(Refereed journal article or data article (A1))