Ph.D. dos Jarmo Käpylä - UTU Research Portal

Jarmo Käpylä
Ph.D. dos

- University Lecturer,
Biochemistry (Department of Life Technologies)

jakapy@utu.fi

+358 29 450 4704

+358 40 191 1153

Tykistökatu 6

Turku

: https://orcid.org/0000-0003-3036-713X

Protein structure and function

Extracellular matrix, integrins

Lectures: Molecular biology, Proteins

Lab courses: Molecular biology techniques, Protein techniques

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Structure of Collagen Receptor Integrin alpha I-1 Domain Carrying the Activating Mutation E317A (2011)
- Journal of Biological Chemistry
Lahti M, Bligt E, Niskanen H, Parkash V, Brandt AM, Jokinen J, Patrikainen P, Kapyla J, Heino J, Salminen TA
The structure of collagen receptor integrin alpha1I domain in active conformation (2011)
- Journal of Biological Chemistry
Matti Lahti, Eva Bligt, Henri Niskanen, Anna Brandt, V Parkash, Johanna Jokinen, Pekka Patrikainen, Jarmo Käpylä, Jyrki Heino, Tiina Salminen
A small-molecule inhibitor of integrin alpha 2 beta 1 introduces a new strategy for antithrombotic therapy (2010)
- Thrombosis and Haemostasis
Nissinen L, Pentikainen OT, Jouppila A, Kapyla J, Ojala M, Nieminen J, Lipsanen A, Lappalainen H, Eckes B, Johnson MS, Lassila R, Marjamaki A, Heino J
Lumican inhibits cell migration through alpha 2 beta 1 integrin (2010)
- Experimental Cell Research
Zeltz C, Brezillon S, Kapyla J, Eble JA, Bobichon H, Terryn C, Perreau C, Franz CM, Heino J, Maquart FX, Wegrowski Y
Molecular mechanism of alpha 2 beta 1 integrin interaction with human echovirus 1 (2010)
- EMBO Journal
Jokinen J, White DJ, Salmela M, Huhtala M, Käpylä J, Sipila K, Puranen JS, Nissinen L, Kankaanpaa P, Marjomaki V, Hyypia T, Johnson MS, Heino J
Effects of conformational activation of integrin alpha 1I and alpha 2I domains on selective recognition of laminin and collagen subtypes. – Integrin alpha I domain activation (2008)
- Experimental Cell Research
Tulla M, Lahti M, Puranen JS, Brandt A, Kapyla J, Domogatskaya A, Salminen TA, Tryggvason K, Johnson MS, Heino J
Small molecule designed to target metal binding site in the alpha 2I domain inhibits integrin function (2007)
- Journal of Medicinal Chemistry
Kapyla J, Pentikainen OT, Nyronen T, Nissinen L, Lassander S, Jokinen J, Lahti M, Marjamaki A, Johnson MS, Heino J,
The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: Structural studies and mechanistic implications (1998) Tuominen V, Heikinheimo P, Kajander T, Torkkel T, Hyytia T, Kapyla J, Lahti R, Cooperman BS, Goldman A
Structure and function analysis of Escherichia coli inorganic pyrophosphatase: is a hydroxide ion the key to catalysis? (1995)
- Biochemistry
Salminen T, Käpylä J, Heikinheimo P, Kankare J, Goldman A, Heinonen J, Baykov AA, Cooperman BS, Lahti R.