Ph.D. dos Jarmo Käpylä - UTU Research Portal

Jarmo Käpylä
Ph.D. dos

- University Lecturer,
Biochemistry (Department of Life Technologies)

jakapy@utu.fi

+358 29 450 4704

+358 40 191 1153

Tykistökatu 6

Turku

: https://orcid.org/0000-0003-3036-713X

Protein structure and function

Extracellular matrix, integrins

Lectures: Molecular biology, Proteins

Lab courses: Molecular biology techniques, Protein techniques

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Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets (2024)
- Matrix Biology
Salo Antti M., Rappu Pekka, Koski M．Kristian, Karjalainen Emma, Izzi Valerio, Drushinin Kati, Miinalainen Ilkka, Käpylä Jarmo, Heino Jyrki, Myllyharju Johanna
Exploring the Interactions between Plant Proanthocyanidins and Thiabendazole : Insights from Isothermal Titration Calorimetry (2024)
- Molecules
Sillanpää, Mimosa; Engström, Marica T.; Tähtinen, Petri; Green, Rebecca J.; Käpylä, Jarmo; Näreaho, Anu; Karonen, Maarit
Tannins Can Have Direct Interactions with Anthelmintics: Investigations by Isothermal Titration Calorimetry (2023)
- Molecules
Sillanpää Mimosa, Engström Marica T.,Tähtinen Petri, Green Rebecca J., Käpylä Jarmo, Näreaho Anu, Karonen Maarit
Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism (2022)
- Developmental Cell
Sipilä Kalle, Rognoni Emanuel, Jokinen Johanna, Tewary Mukul, Rudan Matteo Vietri, Talvi Salli, Jokinen Ville, Dahlström Käthe M, Liakath-Ali Kif, Mobasseri Atefeh, Du-Harpur Xinyi, Käpylä Jarmo, Nutt Stephen L, Salminen Tiina A, Heino Jyrki, Watt Fiona M
Integrin alpha 11 beta 1 is a receptor for collagen XIII (2020)
- Cell and Tissue Research
Koivunen J, Tu H, Kemppainen A, Anbazhagan P, Finnila MA, Saarakkala S, Kapyla J, Lu N, Heikkinen A, Juffer AH, Heino J, Gullberg D, Pihlajaniemi T
The binding mechanism of adhesin P subtype to globotetraosylceramide is associated with systemic disease (2020)
- Journal of Biological Chemistry
Johansson MM, Bélurier E, Papageorgiou AC, Sundin AP, Rahkila J, Kallonen T, Nilsson UJ, Maatsola S, Nyholm TKM, Käpylä J, Corander J, Leino R, Finne J, Teneberg S, Haataja S
Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms (2018)
- Journal of Biological Chemistry
Kalle H. Sipilä, Kati Drushinin, Pekka Rappu, Johanna Jokinen, Tiina A. Salminen, Antti M. Salo, Jarmo Käpylä, Johanna Myllyharju, Jyrki Heino
Joint inflammation related citrullination of functional arginines in extracellular proteins (2017)
- Scientific Reports
Sipila KH, Ranga V, Rappu P, Mali M, Pirila L, Heino I, Jokinen J, Kapyla J, Johnson MS, Heino J
The binding capacity of alpha 1 beta 1-, alpha 2 beta 1-and alpha 10 beta 1-integrins depends on non-collagenous surface macromolecules rather than the collagens in cartilage fibrils (2017)
- Matrix Biology
Woltersdorf C, Bonk M, Leitinger B, Huhtala M, Kapyla J, Heino J, Girol CG, Niland S, Eble JA, Bruckner P, Dreier R, Hansen U
Extracellular citrullination inhibits the function of matrix associated TGF-beta (2016)
- Matrix Biology
Sipila KH, Ranga V, Rappu P, Torittu A, Pirila L, Kapyla J, Johnson MS, Larjava H, Heino J
Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation. (2015)
- Pharmacology Research and Perspectives
Nissinen L, Ojala M, Langen B, Dost R, Pihlavisto M, Käpylä J, Marjamäki A, Heino J.
Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. (2014)
- FASEB Journal
Kalle Sipilä, Sabrina Haag, Konstantin Denessiouk, Jarmo Käpylä, Eric C. Peters, Alexander Denesyuk, Uwe Hansen, Yrjö Konttinen, Mark S. Johnson, Rikard Holmdahl, Jyrki Heino
Early Chordate Origin of the Vertebrate Integrin αI Domains (2014)
- PLoS ONE
Bhanupratap Singh Chouhan,Jarmo Käpylä,Konstantin Denessiouk, Alexander Denesyuk,Jyrki Heino,Mark S. Johnson
In vitro blood and fibroblast responses to BisGMA-TEGDMA/bioactive glass composite implants. (2014)
- Journal of Materials Science: Materials in Medicine
Abdulmajeed AA, Kokkari AK, Kapyla J, Massera J, Hupa L, Vallittu PK, Närhi TO
Evolution of Cell Adhesion to Extracellular Matrix (2013) Evolution of Extracellular Matrix Johnson MS, Kapyla J, Denessiouk K, Airenne T, Chouhan BS, Heino J
Leukocyte integrins alpha(L)beta(2), alpha(M)beta(2) and alpha(X)beta(2) as collagen receptors - Receptor activation and recognition of GFOGER motif (2013)
- International Journal of Biochemistry and Cell Biology
Lahti M, Heino J, Kapyla J
Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone (2013)
- BBA - Biochimica et Biophysica Acta
Mikko Ylilauri, Elina Mattila, Elisa M Nurminen, Jarmo Käpylä, Sanna P Niinivehmas, Juha A Määttä, Ulla Pentikäinen, Johanna Ivaska, and Olli T Pentikäinen
Novel alpha 2 beta 1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation (2012)
- Journal of Biological Chemistry
Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K, Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J
Collagen XXIII, Novel Ligand for Integrin alpha(2)beta(1) in the Epidermis (2011)
- Journal of Biological Chemistry
Veit G, Zwolanek D, Eckes B, Niland S, Kapyla J, Zweers MC, Ishada-Yamamoto A, Krieg T, Heino J, Eble JA, Koch M
Fluorescent Small Molecule Probe to Modulate and Explore alpha 2 beta 1 Integrin Function (2011)
- Journal of the American Chemical Society
Koivunen JT, Nissinen L, Kapyla J, Jokinen J, Pihlavisto M, Marjamaki A, Heino J, Huuskonen J, Pentikainen OT